Publications by authors named "Leydy Lorena Mendoza Tobar"
Immunomodulatory effect of sp. in mononuclear cells extracted from the blood of rheumatoid arthritis patients.
J Venom Anim Toxins Incl Trop Dis
September 2024
Background: Pathophysiological mechanisms of rheumatoid arthritis arise because of a proinflammatory environment, generated by the interaction of autoreactive lymphocytes and proinflammatory mediators. Current strategies to mitigate the progression of the disease produce adverse effects, so there is a need for new therapeutic strategies and molecular targets to treat this disease. In this context, evidence suggests that scorpion venoms could modulate the immune response and some important cellular mechanisms of pharmacological interest.
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- In Colombia, certain scorpion species from the Buthidae family have venom that can be life-threatening due to neurotoxins, yet the enzymes in their venom are less understood.
- Researchers compared the venoms of three Colombian scorpion species to identify the presence of key enzymes like phospholipases, hyaluronidases, and proteases linked to toxicity.
- Findings revealed that different species showed varying enzyme activities, offering insights into how these enzymes contribute to venom toxicity and potentially aiding in the development of better treatment methods for stings.
Antimicrobial, toxicological, and antigenic characteristics of three scorpion venoms from Colombia: Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus.
Acta Trop
April 2024
The venom fractions of three buthid scorpion species from Colombia, C. margaritatus, T. pachyurus and T.
View Article and Find Full Text PDFAmong other scorpion species, Colombia has two genera of the Buthidae family and considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: , , and .
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