Publications by authors named "Leyan Xuan"
Microporous hydrogels have been utilized in an unprecedented manner in the last few decades, combining materials science, biology, and medicine. Their microporous structure makes them suitable for wide applications, especially as cell carriers in tissue engineering and regenerative medicine. Microporous hydrogel scaffolds provide spatial and platform support for cell growth and proliferation, which can promote cell growth, migration, and differentiation, influencing tissue repair and regeneration.
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- Vibrio cholerae is a major cause of cholera, which leads to significant global mortality, and understanding its virulence regulation could pave the way for new treatments.
- The study identifies ChsR, a regulator involved in chitosan utilization, as a factor that enhances V. cholerae virulence by upregulating TcpP, which is crucial for producing cholera toxin.
- Chitosan oligosaccharides were found to inhibit this virulence pathway, and their administration in mice reduced V. cholerae colonization and disease severity, indicating their potential as a therapeutic option for cholera.
Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers, that are promising for tissue engineering and regenerative medicine. Microgels can also be aggregated into microporous scaffolds, promoting cell infiltration and proliferation for tissue repair. This review gives an overview of recent developments in the fabrication techniques and applications of microgels.
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