Publications by authors named "Lexin Zhao"
Article Synopsis
- G protein-coupled receptors, especially galanin receptors (GALRs), are significant in understanding atrial fibrillation (AF), with spexin identified as a unique ligand affecting these receptors.
- Research involving genetically modified mice showed that the absence of spexin increased the likelihood of AF and disrupted potassium currents and calcium handling in heart cells.
- The study concluded that spexin lowers AF risk by inhibiting the phosphorylation of CREB, leading to decreased expression of specific channels and improved cardiac function.
Article Synopsis
- Cardiomyocyte maturation is essential for heart development, and abnormal maturation can lead to serious heart diseases, with Cfp1 being an under-researched factor in this process.
- The study found that cardiomyocyte-specific Cfp1 knockout mice died within four weeks due to inhibited maturation, whereas Cfp1 transgenic mice and hiPSC-CMs with Cfp1 overexpression exhibited a more mature phenotype.
- Cfp1 affects gene expression crucial for cardiomyocyte maturation by regulating H3K4me3 histone modification, indicating that its dysfunction is closely linked to cardiac diseases.
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and neddylation-dissociated protein 1 (CAND1) in the development of NAFLD and the underlying mechanisms. CAND1 is reduced in the liver of NAFLD male patients and high fat diet (HFD)-fed male mice.
View Article and Find Full Text PDFInfertility affects roughly 8-12 % of couples worldwide, and in above 50 % of couples, male factors are the primary or contributing cause. Many long noncoding RNAs (lncRNAs) are detected in the testis, but their functions are not well understood. CIRBIL was 862 nucleotides in length and was found to be localized mostly in the cytosol of Leydig cell, a small portion was positioned inside the seminiferous tubules.
View Article and Find Full Text PDFObjective: ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to promote its transcriptional activity in the nucleus. However, whether cytoplasmic ASPP1 affects p53 nuclear trafficking and its role in cardiac diseases remains unknown. This study aims to explore the mechanism by which ASPP1 modulates p53 nuclear trafficking and the subsequent contribution to cardiac ischemia/reperfusion (I/R) injury.
View Article and Find Full Text PDFThis study focuses on a safety evaluation method for underground gas storage. Gas storage is usually constructed underground in complex environments, and the service life of such facilities is limited. To ensure the secure and long-term operation of gas storage facilities, safety evaluation has become the focus of management.
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