Publications by authors named "Lewandowska A"

Background: The purpose of this study is to determine the effect of the type of I-125 radioactive source on dose distribution in the planning process of ultra-low dose rate (uLDR) prostate brachytherapy.

Material And Methods: 7 patients who had undergone brachytherapy in our center were included in the study. Dose in five geometrical points were analyzed for 12 types of implants that are available on the market.

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Testicular cancer accounts for approximately 5 % of all urologic cancers. The most common histopathological diagnosis of testicular neoplastic lesions are germ cell tumors (90-95 % of cases), among which the majority of cases are seminomas, the most common malignant tumors among men aged 15-44. For better clinical diagnosis and treatment, it is important to understand the molecular mechanisms of tumor formation.

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Genetically modified strain MXY0541 was developed to produce soy leghemoglobin by introducing the coding sequence encoding leghemoglobin from soybean (). The molecular characterisation data and bioinformatic analyses do not raise any safety concerns. The safety of soy leghemoglobin as a food additive has already been assessed by the EFSA FAF Panel (EFSA-Q-2022-00031).

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Genetically modified maize DP51291 was developed to confer control against susceptible corn rootworm pests and tolerance to glufosinate-containing herbicide; these properties were achieved by introducing the and expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP51291 and its conventional counterpart needs further assessment, except for phosphorus in forage and manganese, proline, oleic acid (C18:1) and linoleic acid (C18:2) in grain, which do not raise safety and nutritional concerns.

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  • Childhood cancer is a significant source of stress for families, affecting parental emotional well-being and coping abilities, which in turn can impact the child's emotional state.
  • A study of 270 parents whose children are undergoing cancer treatment revealed high levels of depression and anxiety, with 33% experiencing mild to severe depression and nearly half showing signs of anxiety.
  • The findings suggest that the length of the child's illness correlates with increased levels of both anxiety and depression among parents, indicating a need for better emotional support resources for families facing such challenges.
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  • The study analyzed the link between food consumption and metabolic/cardiovascular disorders among 405 nurses through various health assessments and surveys.
  • More than half of the nurses were found to be overweight or obese, with nearly 40% having high blood pressure.
  • The results suggest that certain food groups may increase the risk of conditions like hypertension and obesity, emphasizing the need for better nutritional strategies to improve nurses' health and enhance their work effectiveness.
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Scientific research confirms the harmful effects of airborne cyanobacteria and microalgae. However, determining human exposure to these microorganisms remains a challenge. The six-stage Tisch impactor was used to collect bioaerosols from April to September 2020 in the coastal zone of the southern Baltic.

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Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the expression cassettes. The molecular characterisation data and bioinformatic analyses did not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP910521 and its conventional counterpart needs further assessment except for the levels of iron in grain, which do not raise safety and nutritional concerns.

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Genetically modified maize MON 95275 was developed to confer protection to certain coleopteran species. These properties were achieved by introducing the , and expression cassettes. The molecular characterisation data and bioinformatic analyses reveal similarity to known toxins, which was further assessed.

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Ongoing climate warming alters precipitation and water column stability, leading to salinity and nutrient supply changes in the euphotic zone of many coastal ecosystems and semi-enclosed seas. Changing salinity and nutrient conditions affect phytoplankton physiology by altering elemental ratios of carbon (C), nitrogen (N) and phosphorus (P). This study aimed to understand how salinity stress and resource acquisition affect phytoplankton stoichiometry.

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BACKGROUND Hypertension is one of the main modifiable risk factors linked to cardiovascular disease and its prevalence is currently increasing in various age groups. This study aimed to evaluate blood pressure, demographic data, workload, and lifestyle factors in nurses employed in hospitals in the Subcarpathian region of southeastern Poland. MATERIAL AND METHODS This cross-sectional observational study was conducted among 627 professionally active nurses.

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Mycelium-based composites (MBCs) are biomaterials with scientifically proven potential to improve sustainability in construction. Although mycelium-based products are not entirely new, their use in engineering presents challenges due to the inherent properties of this fungal material. This study investigated professional architects' and interior designers' perceptions of MBCs, focusing on familiarity, aesthetic appeal, and willingness to use.

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Calcium channels are specialized ion channels exhibiting selective permeability to calcium ions. Calcium channels, comprising voltage-dependent and ligand-gated types, are pivotal in neuronal function, with their dysregulation is implicated in various neurological disorders. This review delves into the significance of the genes, including , , , , , and , in the pathogenesis of conditions such as migraine, epilepsy, cerebellar ataxia, dystonia, and cerebellar atrophy.

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Taking into account homeostatic disorders resulting from arterial hypertension and the key importance of CacyBP/SIP, β-catenin and endocannabinoids in the functioning of many organs, it was decided to assess the presence and distribution of CacyBP/SIP, β-catenin, CB1 and CB2 in the adrenal glands of hypertensive rats of various aetiology. The study was conducted on the adrenal glands of rats with spontaneous and renovascular hypertension. The expression of CacyBP/SIP, β-catenin, CB1 and CB2 was detected by immunohistochemistry and real-time PCR method.

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Reproductive factors play significantly important roles in determining the breast cancer (BC) risk. The impact of pregnancy, abortion, and birth control methods on tumor development remains unclear. It has been found that early full-term pregnancies in young women can lower their lifetime risk of developing the type of cancer in question.

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Genetically modified (GM) maize MON 94804 was developed to achieve a reduction in plant height by introducing the suppression cassette. The molecular characterisation and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the agronomic/phenotypic and compositional differences identified between maize MON 94804 and its conventional counterpart needs further assessment, except for ear height, plant height and levels of carbohydrates in forage, which do not raise safety or nutritional concerns.

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: The pandemic has proven to be a particular challenge for healthcare workers, not only in the professional but also individual sense. The COVID-19 pandemic negatively influenced their well-being and caused psychological distress. Undoubtedly, direct contact with sick patients, the fight against the pandemic, and observing the epidemiological situation influenced the attitudes of this group towards COVID-19 and vaccinations.

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Unlabelled: Radiotherapy (RT) plays a key role in brain tumours but can negatively impact functional outcomes and quality of life. The aim of this study was to analyse anti-neural and onconeural autoantibodies and markers of blood-brain barrier (BBB) disruption in patients with primary brain cancer undergoing RT.

Materials And Methods: A prospective study was conducted on 45 patients with a brain tumour scheduled for intensity-modulated radiotherapy.

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The present work provides new evidence of the ongoing potential of surface-active ionic liquids (SAILs) and surface-active quaternary ammonium salts (surface-active QASs). To achieve this, a series of compounds were synthesized with a yield of ≥85%, and their thermal analyses were studied. Additionally, antimicrobial activity against both human pathogenic and soil microorganisms was investigated.

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Article Synopsis
  • - Genetically modified maize DP23211 was engineered to resist specific pests and tolerate a certain herbicide, with no critical safety issues found in molecular and bioinformatic analyses.
  • - Differences in nutrient levels were noted but did not pose safety or nutritional concerns, and the GMO Panel deemed the new proteins and RNA from the modification to be safe for consumption.
  • - Overall, maize DP23211 is considered just as safe for human and animal health as conventional maize, and no additional monitoring for safety or environmental impact is required.
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Genetically modified maize DP915635 was developed to confer tolerance to glufosinate herbicide and resistance to corn rootworm pests. These properties were achieved by introducing the and expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment.

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  • Previous attempts at creating safer antifungal treatments were based on an outdated model, focusing on how they damage fungal cell membranes.
  • Researchers discovered that the key to the antifungal action of amphotericin B, a potent but kidney-damaging drug, lies in its ability to form sponge-like aggregates that extract crucial components from fungi.
  • By modifying amphotericin B to selectively extract ergosterol without harming human kidneys, scientists developed a new polyene compound, AM-2-19, which shows promise as a safer and effective treatment against various fungal infections.
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Various stimulants (VS) are chemicals that disrupt the endocrine system - endocrine homeostasis of the reproductive system - which also known as endocrine-disrupting chemicals (EDCs). These substances are found in the human body, in both the blood and urine, amniotic fluid, or, among others, the adipose tissue. This article presents the current state of knowledge of the effect of EDCs and additional factors such as smoking, alcohol consumption, and cannabis on the gonads.

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Background: SARS-CoV-2 infection in pregnant women may induce inflammation within the amniotic cavity and/or an increase in proinflammatory cytokines in fetal circulation. The aim was to investigate levels of IL-6 in maternal blood, umbilical cord blood, and amniotic fluid in pregnant women infected with SARS-CoV-2 at delivery.

Methods: A single-center prospective observational case-control study of pregnant women diagnosed with SARS-CoV-2 infection at delivery was conducted.

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Objective: The incidence of skin cancer is constantly growing, it is considered a serious problem of public health. Most cases of skin cancer are caused by a combination of non-modifiable genetic, and modifiable environmental risk factors. The study objective was to analyse the correlation between pigmentation traits, excessive sunlight exposure, solarium use and the risk of melanoma development.

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