Publications by authors named "Levshina A"
We aimed to systematize the results of published studies on the use of (SB) for the treatment of various liver disorders (CRD42022378050). Searches were conducted using PubMed and Scopus on 1 August 2022. The PubMed search was updated on 15 June 2024.
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- * Specific cytokines such as IL-1b, IL-6, and TNF-a were associated with both higher levels of harmful gut bacteria and the severity of cirrhosis symptoms like ascites, suggesting a connection between gut health and liver disease progression.
- * The results indicate that certain gut bacteria populations correlate directly with inflammatory cytokine levels, pointing to a potential link between gut dysbiosis and systemic inflammation in cirrhosis patients.
State-of-the-art therapy improves the five-year survival rate of patients under the age of 20 with cranial and craniospinal tumors by up to 74%. The urgency of dealing effectively with late treatment-associated cardiovascular complications is rising. : We aimed to assess echocardiographic parameters and exercise performance in subjects with a history of complex treatment for cranial and craniospinal tumors in childhood.
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- * The cancer often develops due to gene mutations and is typically asymptomatic in early stages, causing a delay in diagnosis and treatment, which can lead to metastasis and further complications.
- * A clinical case highlights the unfortunate consequences of a late ACC diagnosis in a 46-year-old woman, stressing the need for better awareness and timely medical intervention for improved outcomes.
Gut dysbiosis and subclinical intestinal damage are common in cirrhosis. The aim of this study was to examine the association of intestinal damage biomarkers (diamine oxidase [DAO], claudin 3, and intestinal fatty acid binding protein [I-FABP; FABP2]) with the state of the gut microbiota in cirrhosis. The blood levels of DAO were inversely correlated with blood levels of claudin 3, lipopolysaccharide (LPS), presepsin, TNF-α, and the severity of cirrhosis according to Child-Pugh scores.
View Article and Find Full Text PDFA single-lead ECG based cardiotoxicity detection in patients on polychemotherapy.
Int J Cardiol Heart Vasc
February 2024
Article Synopsis
- Anti-cancer treatments can lead to serious heart issues, which are a leading cause of death in cancer survivors, highlighting the need for ongoing heart monitoring during and after treatment.
- A study involving 162 cancer patients showed that remote single-lead ECG monitoring effectively detected early signs of cardiotoxicity, with significant occurrences of QTc prolongation and new atrial fibrillation after chemotherapy.
- Early identification of heart problems from cancer treatments can significantly improve patient safety, and using portable ECG devices is a practical and cost-effective way to monitor these risks.
The number of people suffering from allergies is increasing worldwide every year. With the prevalence of domestic animals, especially dogs, allergens associated with them can be found ubiquitously, thereby increasing the risk of anaphylaxis in sensitized individuals. Currently, there are 8 known dog allergens, but not all of them have been thoroughly studied.
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- The study evaluated how gut bacteria imbalances (dysbiosis) affect blood circulation changes (hyperdynamic circulation) in patients with cirrhosis and how these changes relate to disease complications.
- It involved 47 cirrhosis patients whose stool microbiomes were examined, revealing patients with hyperdynamic circulation had more severe liver conditions and specific blood marker changes compared to those with normal circulation.
- Key findings showed changes in gut bacteria, with increased levels of Proteobacteria and decreased levels of Bacteroidetes, were linked to blood flow dynamics, suggesting that certain gut bacteria may influence systemic vascular resistance and heart function.
Decreased muscle mass and function, also known as sarcopenia, is common in patients with cirrhosis and is associated with a poor prognosis. Although the pathogenesis of this disorder has not been fully elucidated, a disordered gut-muscle axis probably plays an important role. Decreased barrier function of the gut and liver, gut dysbiosis, and small intestinal bacterial overgrowth (SIBO) can lead to increased blood levels of ammonia, lipopolysaccharides, pro-inflammatory mediators, and myostatin.
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- Small intestinal bacterial overgrowth (SIBO) occurs when there is an abnormal increase in bacteria in the small intestine, affecting around 33.8% of patients with gastrointestinal issues, and is linked to smoking and symptoms like bloating and abdominal pain.
- * SIBO can complicate various diseases (like IBS, Crohn's disease, and diabetes) and is notably influenced by factors like age, motor dysfunction in the intestine, and the use of proton pump inhibitors.
- * The connection between SIBO and the severity of certain diseases highlights the need for further research on how treating SIBO could improve patient outcomes.
Objectives: The aim is to study impact of vaccination against the novel coronavirus disease (COVID-19) with Sputnik V on mortality during the period of predominance of the delta variant of SARS-CoV-2.
Methods: This was a retrospective cohort study of individuals with state health insurance at the Moscow Ambulatory Center. The cohorts included 41,444 persons vaccinated with Sputnik V, 15,566 survivors of COVID-19, and 71,377 non-immune persons.
Diarrhea is one of the manifestations of the novel coronavirus disease (COVID-19), but it also develops as a complication of massive antibiotic therapy in this disease. This study aimed to compare these types of diarrhea.We included patients with COVID-19 in a cohort study and excluded patients with chronic diarrhea, laxative use, and those who died during the first day of hospitalization.
View Article and Find Full Text PDFCytokine release syndrome is a serious complication of the new coronavirus infection (COVID-19). The aim of the study was to assess effectiveness and safety of the IL-17 antagonist nekatimab for its treatment. The retrospective study included COVID-19 patients with C-reactive protein levels >60 mg/L.
View Article and Find Full Text PDFBackground And Aim: Cytokine release syndrome is a dangerous complication of the coronavirus disease 2019 (COVID-19). This study aimed to evaluate the efficacy and safety of tofacitinib in the management of this complication.
Methods: The retrospective study included COVID-19 patients with C-reactive protein (CRP) levels of 60-150 mg/L.
[The effect of ultrasound on the physicochemical indices of therapeutic naphthalan oil and its components].
Vopr Kurortol Fizioter Lech Fiz Kult
December 1989