Generalized trust and traffic violations: The moderating role of the individualism dimension.

Traffic crashes take well over a million lives every year and are mainly caused by driver behavior and traffic violations. Drivers' attitudes and beliefs are at the root of whether traffic violations will be committed, making it important to explore what contributes to disobedience of traffic law. Generalized trust is one of the most influential factors in interpersonal behavior but has not yet been studied empirically in the context of driving behavior in general, and traffic violations in specific.

An attenuated cytomegalovirus vaccine with a deletion of a viral chemokine gene is protective against congenital CMV transmission in a guinea pig model.

Development of a vaccine against congenital cytomegalovirus (CMV) infection is a public health priority, but CMVs encode immune evasion genes that complicate live virus vaccine design. To resolve this problem, this study employed guanosyl phosphoribosyl transferase (gpt) mutagenesis to generate a recombinant guinea pig CMV (GPCMV) with a knockout of a viral chemokine gene, GPCMV MIP (gp1). MIP deletion virus replicated with wild-type kinetics in cell culture but was attenuated in nonpregnant guinea pigs, demonstrating reduced viremia and reduced inflammation and histopathology (compared to a control virus with an intact GPCMV MIP gene) following footpad inoculation.

Osteosarcoma: relation between extent of marrow infiltration on CT and frequency of lung metastases.

Thirty-seven patients with osteosarcoma were evaluated by CT of both the involved bone and the lungs. The ratio of the extent (E) of the involved marrow segment to the length (L) of involved bone (E/L) was correlated with the presence and subsequent development of pulmonary metastases. The marrow was evaluated by CT for the presence of tumor by measuring mean attenuation coefficients on serial axial scans.