Publications by authors named "Leventis I"
Newly detected diabetes mellitus patients with acute coronary syndrome have an adverse cardiometabolic profile similar to patients with prior diabetes and a more extensive ischemic myocardial insult.
Diabetes Res Clin Pract
May 2024
Aims: The impact of newly detected diabetes mellitus (NDDM) on metabolic parameters and extent of myocardial necrosis in patients with acute coronary syndrome (ACS) is not fully explored. We examined the impact of NDDM on cardiometabolic characteristics and myocardial necrosis in ACS patients.
Methods: CALLINICUS-Hellas Registry is an ongoing prospective multicenter observational study evaluating the adherence to lipid-lowering therapy (LLT) among ACS patients in Greece.
Recent studies have demonstrated the prognostic value of spot urinary sodium (UNa) in acutely decompensated chronic HF (ADCHF) patients. However, data on the prognostic role of UNa and spot urinary chloride (UCl) in patients with advanced HF are limited. In the present prospective pilot study, we examined the predictive value of UNa and UCl concentration at baseline, at 2 h and at 24 h after admission for all-cause mortality and HF rehospitalization up to 3 months post-discharge.
View Article and Find Full Text PDFAn outbreak of coronavirus disease 2019 (COVID-19) occurred in December 2019 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a strain of SARS-CoV. Patients infected with the virus present a wide spectrum of manifestations ranging from mild flu-like symptoms, cough, fever and fatigue to severe lung injury, appearing as bilateral interstitial pneumonia or acute respiratory failure. Although SARS-CoV-2 infection predominantly offends the respiratory system, it has been associated with several cardiovascular complications as well.
View Article and Find Full Text PDFMyocarditis is a rare adverse event of vaccination. Recently, mRNA vaccines for COVID-19 have been reported to correlate with myocarditis, specifically in adolescents and young men. We report a rare case of a 50-year-old man who presented with symptoms of myocardial infarction 3 days after the second dose of vaccination for COVID-19.
View Article and Find Full Text PDFBackground: Non-vitamin K antagonist oral anticoagulants (NOAC) have superior safety and comparable efficacy profile compared to vitamin-K antagonists (VKAs), with more convenient dosing schemes. However, issues with adherence to the NOACs remain unsolved.
Aims: We sought to investigate the adherence to oral anticoagulation (OAC) and baseline factors associated with poor adherence after ischaemic stroke in patients with atrial fibrillation (AF).
Article Synopsis
- The study investigates the impact of statin treatment on patients with embolic stroke of undetermined source (ESUS), focusing on stroke recurrence, major cardiovascular events (MACE), and mortality.
- Among 264 ESUS patients followed for 4 years, those discharged on statins experienced significantly lower rates of stroke recurrence (3.58 vs. 7.23 per 100 patient-years), MACE (4.98 vs. 9.89 per 100 patient-years), and death (3.93 vs. 8.21 per 100 patient-years).
- The results suggest that statin use at discharge is an effective independent predictor for reducing the risk of stroke recurrence, MACE, and death in ESUS
Article Synopsis
- Atrial cardiopathy and likely pathogenic patent foramen ovale (PFO) are potential causes of embolic strokes of unknown origin, but their relationship in patients remains unclear.
- In a study involving 367 patients with embolic stroke of undetermined source (ESUS), it was found that only a small percentage had both conditions, with many having one or the other, but not both.
- The data suggests that the presence of atrial cardiopathy is inversely related to the presence of likely pathogenic PFO, meaning if one is present, the likelihood of the other decreases.
Article Synopsis
- The study aimed to compare how effective and safe oral anticoagulants are versus antiplatelets in stroke patients with supracardiac atherosclerosis, including atherosclerotic plaques in arteries.
- Through a literature search, researchers identified 10 randomized controlled trials involving over 6,000 patients, analyzing outcomes like recurrent strokes, major ischemic events, and bleeding incidents.
- Results indicated that anticoagulant patients had similar ischemic stroke rates compared to antiplatelet patients, but experienced significantly higher rates of major bleeding incidents.
Article Synopsis
- Many patients with atrial fibrillation (AF) are still prescribed aspirin for treatment despite guidelines recommending direct oral anticoagulants (DOACs) due to perceived safety benefits.
- A systematic review and meta-analysis of randomized controlled trials showed that using DOACs at approved doses resulted in higher risks of bleeding compared to aspirin.
- The findings suggest that aspirin should not be favored over DOACs for AF treatment, indicating a need to improve clinical recommendations and potentially reduce the number of AF patients treated with antiplatelet drugs.
Article Synopsis
- * In our analysis of 772 patients, we found that female sex was a strong predictor of severe ESUS, affecting more than half of the study group with NIHSS scores indicating severity.
- * While the rates of stroke recurrence and new atrial fibrillation were similar for both mild and severe ESUS, the death rate was significantly higher in severe cases, highlighting the need for better management of these patients.
The use of isobutylcyanoacrylate as a tissue adhesive in abdominal surgery.
Acta Chir Belg
August 2005
Background: The use of cyanoacrylate substances as tissue adhesives is of valuable aid in surgery, especially in cases of injuries of the intraabdominal organs, where the haemorrhage is very difficult to control.
Materials And Methods: We investigated the efficiency of isobutyl-2-cyanoacrylate as a tissue adhesive in the haemostasis and adhesion of different types of wounds in solid and hollow organs. Forty-six dogs underwent single-organ (26 dogs) and combined-organ (20 dogs) procedures; cuneiform excisions of the liver and the spleen, as well as incisions of the small intestine were carried out.
Liver ischemia followed by reperfusion is an important and common clinical event. A major mechanism is leukocyte adhesion to endothelium followed by release of reactive oxygen metabolites. The aim of this study was to determine the effects of a novel antioxidant ethylenediamine derivative with anti-inflammatory properties (compound IA) on an imitated clinical setting of acute hepatic ischemia-reperfusion injury.
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