Publications by authors named "Levente Gulacsi"
Front Immunol
December 2021
Article Synopsis
- The study investigates how kynurenic acid (KYNA) and its synthetic analogues SZR-72 and SZR-104 impact blood-brain barrier (BBB) permeability and mitochondrial function in a rodent model of sepsis.
- It was found that sepsis leads to increased organ failure scores and elevated brain injury markers, indicating CNS dysfunction, which was reduced by treatment with KYNA and its analogues.
- The results suggest that KYNA may protect against sepsis-related brain damage by decreasing the levels of inflammatory markers and improving mitochondrial function.
