Screening and cervical cancer cure: population based cohort study.

Objective: To determine whether detection of invasive cervical cancer by screening results in better prognosis or merely increases the lead time until death.

Design: Nationwide population based cohort study.

Setting: Sweden.

Genotyping of human papillomavirus in triaging of low-grade cervical cytology.

Objective: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse).

Study Design: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated.

Results: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women.

Risk of invasive cervical cancer in relation to clinical investigation and treatment after abnormal cytology: a population-based case-control study.

A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the subsequent risk of invasive cervical cancer. All invasive cervical cancer cases in Sweden 1999-2001 and five population-based control women per case were investigated.

Randomized healthservices study of human papillomavirus-based management of low-grade cytological abnormalities.

Human papillomavirus (HPV)-based management of women with borderline atypical squamous cells of undetermined significance (ASCUS) or mildly abnormal cervical intraepithelial neoplasia (CINI) cervical cytology has been extensively studied in the research setting. We wished to assess safety and health care resource use of a real-life health care policy using HPV triaging. All 15 outpatient clinics involved in the organized population-based screening program in Stockholm, Sweden screening program were randomized to either continue with prior policy (colposcopy of all women with ASCUS/CINI) or to implement a policy with HPV triaging and colposcopy only of HPV-positive women.

Breast Cancer Screening Program in Stockholm County, Sweden - Aspects of Organization and Quality Assurance.

The population-based breast cancer screening program in Stockholm County was initiated in 1989. The program follows the recommendations issued by the Swedish Board of Health and Welfare, and is in agreement with guidelines from the European Commission. Individual data is available for all women in Stockholm County aged 40-69 years since initiation of the program in 1989.

A pooled analysis of interval cancer rates in six European countries.

The objective of this study was to assess detection rates and interval breast cancer (IC) rates from eight programmes in the European Breast Cancer Screening Network. A common data collection protocol was used to explore differences in IC rates among programmes and discuss their potential determinants. Pooled analysis was used to describe IC rates by age, compliance in screening, recall rate, screening detection (SD) rate and expected breast cancer incidence.

Risk of invasive cervical cancer in relation to management of abnormal Pap smear results.

Objective: We sought to evaluate the management of women with abnormal cytology in terms of subsequent risk of invasive cervical cancer.

Study Design: The screening histories of all invasive cervical cancer cases diagnosed in Sweden 1999-2001 and of 5 population-based controls per case were reviewed. In all, 159 patients and 258 control subjects aged < 67 years had an abnormal smear result 0.

Temporal trends in the use of adjuvant systemic therapy in breast cancer: a population based study in Sweden 1976-2005.

Background: Both adjuvant therapy and mammography screening can decrease breast cancer mortality and there is a need of knowing to what extent those two modalities are used in the population. Screening coverage is well documented but there is a scarcity of population-based data on use of systemic adjuvant treatment.

Aim: To describe the introduction, and trends in the use of adjuvant systemic therapy for breast cancer in two of six public health regions in Sweden.

Screening-preventable cervical cancer risks: evidence from a nationwide audit in Sweden.

Background: The effectiveness of cervical cancer screening programs differs widely in different populations. The reasons for these differences are unclear. Routine and comprehensive audits have been proposed as an ethically required component of screening.

Breast cancer incidence and mortality in the Nordic capitals, 1970-1998. Trends related to mammography screening programmes.

The aim of the present study was to relate the time trends in breast cancer incidence and mortality to the introduction of mammography screening in the Nordic capitals. Helsinki offered screening to women aged 50-59 starting in 1986. The other three capitals offered screening to women aged 50-69 starting in 1989 in Stockholm, 1991 in Copenhagen, and 1996 in Oslo.

Pattern of participation in a cohort aged 50-60 years at first invitation to the service-screening programme with mammography in Stockholm county, Sweden.

Background: Mammography screening can only be effective if a high proportion of the invited women attend. The aim of the present study was to search for patterns of participation in women who were invited to five consecutive rounds in a large screening programme.

Method: Stockholm service-screening programme started 1989 and invites women between 50 and 69 years of age to mammography with 2 years interval.