Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.

Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways.

Track Thyself? The Value and Ethics of Self-knowledge Through Technology.

Novel technological devices, applications, and algorithms can provide us with a vast amount of personal information about ourselves. Given that we have ethical and practical reasons to pursue self-knowledge, should we use technology to increase our self-knowledge? And which ethical issues arise from the pursuit of technologically sourced self-knowledge? In this paper, I explore these questions in relation to bioinformation technologies (health and activity trackers, DTC genetic testing, and DTC neurotechnologies) and algorithmic profiling used for recommender systems, targeted advertising, and technologically supported decision-making. First, I distinguish between impersonal, critical, and relational self-knowledge.

Quality of Life in the Management of Home Parenteral Nutrition.

Introduction: Home parenteral nutrition (HPN) is a rare but challenging therapy for patients with mostly severe underlying diseases. We aimed to investigate patient-reported health-related quality of life (QOL) of patients receiving HPN and its development over time in particular.

Methods: We assessed QOL of HPN patients in a prospective multicenter observational study (SWISSHPN II study).

Tree-ring isotopes from the Swiss Alps reveal non-climatic fingerprints of cyclic insect population outbreaks over the past 700 years.

Recent experiments have underlined the potential of δ2H in tree-ring cellulose as a physiological indicator of shifts in autotrophic versus heterotrophic processes (i.e., the use of fresh versus stored non-structural carbohydrates).

Attitudes and expectations of patients on home parenteral nutrition towards eHealth: A multicenter survey.

Background & Aims: Advances in technology enable patients on home parenteral nutrition (HPN) to manage their treatment more independently and safely. eHealth is a promising application of electronic means in healthcare, aimed at improving and simplifying processes and connecting the different parties involved. A thorough understanding of the attitudes and expectations of patients on HPN towards eHealth is a prerequisite for a successful implementation.

Discovery and Structure-Activity Relationship Studies of Novel Adenosine A Receptor-Selective Agonists.

A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists -cyclopentyl adenosine (CPA) and -cyclopentyl 5'--ethylcarboxamidoadenosine (CP-NECA) were synthesized, and their potency and selectivity were assessed. We observed that the most potent were the compounds with a halogen in the position on the aromatic ring of the benzyloxy- or phenoxycyclopentyl substituent. In general, the NECA-based compounds displayed greater AR selectivity than the adenosine-based compounds, with -2-(3-bromobenzyloxy)cyclopentyl-NECA and -2-(3-methoxyphenoxy)cyclopentyl-NECA showing ∼1500-fold improved AR selectivity compared to NECA.

Cellulose in Foliage and Changes during Seasonal Leaf Development of Broadleaf and Conifer Species.

Stable isotope approaches are widely applied in plant science and many improvements made in the field focus on the analysis of specific components of plant tissues. Although technical developments have been very beneficial, sample collection and preparation are still very time and labor-consuming. The main objective of this study was to create a qualitative dataset of alpha-cellulose content of leaf tissues of arboreal species.

Lagrangian Particle Dispersion Models in the Grey Zone of Turbulence: Adaptations to FLEXPART-COSMO for Simulations at 1 km Grid Resolution.

Unlabelled: Lagrangian particle dispersion models (LPDMs) are frequently used for regional-scale inversions of greenhouse gas emissions. However, the turbulence parameterizations used in these models were developed for coarse resolution grids, hence, when moving to the kilometre-scale the validity of these descriptions should be questioned. Here, we analyze the influence of the turbulence parameterization employed in the LPDM FLEXPART-COSMO model.

Selective activation of Gαob by an adenosine A receptor agonist elicits analgesia without cardiorespiratory depression.

The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, some of which are therapeutically undesirable. This is especially the case for adenosine A receptors (ARs) whose clinical potential is undermined by the sedation and cardiorespiratory depression caused by conventional agonists.

First-principles study of the electronic and optical properties of Ho[Formula: see text] impurities in single-layer tungsten disulfide.

The electronic and optical properties of single-layer (SL) tungsten disulfide (WS[Formula: see text]) in the presence of substitutional Holmium impurities (Ho[Formula: see text]) are studied. Although Ho is much larger than W, density functional theory (DFT) including spin-orbit coupling is used to show that Ho:SL WS[Formula: see text] is stable. The magnetic moment of the Ho impurity is found to be 4.

Theoretical Model of a Plasmonically Enhanced Tunable Spectrally Selective Infrared Photodetector Based on Intercalation-Doped Nanopatterned Multilayer Graphene.

We showed in past work that nanopatterned monolayer graphene (NPG) can be used for realizing an ultrafast (∼100 ns) and spectrally selective mid-infrared (mid-IR) photodetector based on the photothermoelectric effect and working in the 8-12 μm regime. In later work, we showed that the absorption wavelength of NPG can be extended to the 3-8 μm regime. Further extension to shorter wavelengths would require a smaller nanohole size that is not attainable with current technology.

Memory Modification and Authenticity: A Narrative Approach.

The potential of memory modification techniques (MMTs) has raised concerns and sparked a debate in neuroethics, particularly in the context of identity and authenticity. This paper addresses the question whether and how MMTs influence authenticity. I proceed by drawing two distinctions within the received views on authenticity.

The unknown third - Hydrogen isotopes in tree-ring cellulose across Europe.

This is the first Europe-wide comprehensive assessment of the climatological and physiological information recorded by hydrogen isotope ratios in tree-ring cellulose (δH) based on a unique collection of annually resolved 100-year tree-ring records of two genera (Pinus and Quercus) from 17 sites (36°N to 68°N). We observed that the high-frequency climate signals in the δH chronologies were weaker than those recorded in carbon (δC) and oxygen isotope signals (δO) but similar to the tree-ring width ones (TRW). The δH climate signal strength varied across the continent and was stronger and more consistent for Pinus than for Quercus.

Losing Meaning: Philosophical Reflections on Neural Interventions and their Influence on Narrative Identity.

The profound changes in personality, mood, and other features of the self that neural interventions can induce can be disconcerting to patients, their families, and caregivers. In the neuroethical debate, these concerns are often addressed in the context of possible threats to the narrative self. In this paper, I argue that it is necessary to consider a dimension of impacts on the narrative self which has so far been neglected: neural interventions can lead to a loss of meaning of actions, feelings, beliefs, and other intentional elements of our self-narratives.

Management of Home Parenteral Nutrition: Complications and Survival.

Background And Aims: Parenteral nutrition (PN) has become an efficient, safe, and convenient treatment over years for patients suffering from intestinal failure. Home PN (HPN) enables the patients to have a high quality of life in their own environment. The therapy management however implies many restrictions and potentially severe lethal complications.

Characterization of Novel Fluorescent Bile Salt Derivatives for Studying Human Bile Salt and Organic Anion Transporters.

Bile salts, such as cholate, glycocholate, taurocholate, and glycochenodeoxycholate, are taken up from the portal blood into hepatocytes via transporters, such as the Na-taurocholate-cotransporting polypeptide (NTCP) and organic anion-transporting polypeptides (OATPs). These bile salts are later secreted into bile across the canalicular membrane, which is facilitated by the bile salt export pump (BSEP). Apart from bile salt transport, some of these proteins (e.

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor.

Despite being among the most characterized G protein-coupled receptors (GPCRs), adenosine receptors (ARs) have always been a difficult target in drug design. To date, no agonist other than the natural effector and the diagnostic regadenoson has been approved for human use. Recently, the structure of the adenosine A1 receptor (AR) was determined in the active, G protein complexed state; this has important repercussions for structure-based drug design.

Plasmonically enhanced mid-IR light source based on tunable spectrally and directionally selective thermal emission from nanopatterned graphene.

We present a proof of concept for a spectrally selective thermal mid-IR source based on nanopatterned graphene (NPG) with a typical mobility of CVD-grown graphene (up to 3000 [Formula: see text]), ensuring scalability to large areas. For that, we solve the electrostatic problem of a conducting hyperboloid with an elliptical wormhole in the presence of an in-plane electric field. The localized surface plasmons (LSPs) on the NPG sheet, partially hybridized with graphene phonons and surface phonons of the neighboring materials, allow for the control and tuning of the thermal emission spectrum in the wavelength regime from [Formula: see text] to 12 [Formula: see text]m by adjusting the size of and distance between the circular holes in a hexagonal or square lattice structure.

Origin and percolation times of Milandre Cave drip water determined by tritium time series and beryllium-7 data from Switzerland.

Early observations of the tritium (H) activity in precipitation from Switzerland started in 1967 in Bern and a monitoring program with improved analytical techniques was carried out between 1971 and 2009. Between 2012 and 2015, we performed tritium analyses on daily precipitation samples from north-western Switzerland to better constrain the tritium variability. We also collected waters dripping inside Milandre Cave (Jura Mountains) with a 4-6 months' resolution in order to estimate the age of the drip water, which is mandatory to interpret the high-resolution speleothem (cave carbonate deposits) records.

The fingerprint of the summer 2018 drought in Europe on ground-based atmospheric CO measurements.

During the summer of 2018, a widespread drought developed over Northern and Central Europe. The increase in temperature and the reduction of soil moisture have influenced carbon dioxide (CO) exchange between the atmosphere and terrestrial ecosystems in various ways, such as a reduction of photosynthesis, changes in ecosystem respiration, or allowing more frequent fires. In this study, we characterize the resulting perturbation of the atmospheric CO seasonal cycles.