Attenuated responses to attention-modulating drugs in the neuroligin-3 mouse model of autism.

Attention deficits are frequently reported within the clinical autism population. Despite not being a core diagnostic feature, some aetiological theories place atypical attention at the centre of autism development. Drugs used to treat attention dysfunction are therefore increasingly prescribed to autistic patients, though currently off-label with uncertain efficacy.

Operationalizing a fisheries social-ecological system through a Bayesian belief network reveals hotspots for its adaptive capacity in the southern North sea.

Fisheries social-ecological systems (SES) in the North Sea region confront multifaceted challenges stemming from environmental changes, offshore wind farm expansion, and marine protected area establishment. In this paper, we demonstrate the utility of a Bayesian Belief Network (BN) approach in comprehensively capturing and assessing the intricate spatial dynamics within the German plaice-related fisheries SES. The BN integrates ecological, economic, and socio-cultural factors to generate high-resolution maps of profitability and adaptive capacity potential (ACP) as prospective management targets.

Fish grabbing: Weak governance and productive waters are targets for distant water fishing.

Distant water fishing occurs worldwide as foreign fleets fish in the exclusive economic zones (EEZs) of other states. We test the hypothesis that host state governance performance is an explanatory factor in observed distant water fishing effort using Global Fishing Watch's fishing effort data obtained from vessels' automatic identification system (AIS). We examine the explanatory power of the World Governance Indicators (WGI), Gross Domestic Product (GDP) per capita, and biophysical fisheries productivity indicators (temperature, oxygen, salinity, nutrients, and primary productivity) on fishing effort from foreign fleets across the four most common gear types (fixed gear, longliners, trawlers, and tuna purse seiners).

Sustainable co-location solutions for offshore wind farms and fisheries need to account for socio-ecological trade-offs.

The spatial expansion of offshore wind farms (OWFs) is key for the transition to a carbon free energy sector. In the North Sea, the sprawl of OWFs is regulated by marine spatial planning (MSP) and results in an increasing loss of space for other sectors such as fisheries. Understanding fisheries benefits of OWFs and mitigating the loss of fishing grounds is key for co-location solutions in MSP.

The prevention of radiation-induced small bowel complications.

Moderate dose pelvic radiotherapy is associated with a 5% severe complication risk related to the small bowel. Strictures and/or fistulation can occur many years after treatment. These complications are difficult to treat, and surgical treatment (excision, bypass) bears a significant morbidity risk.

The volume effect in radiation-related late small bowel complications: results of a clinical study of the EORTC Radiotherapy Cooperative Group in patients treated for rectal carcinoma.

Purpose: The purpose of this study was to quantify the correlation between irradiated small bowel volume and late occurring small bowel complications.

Methods: Small bowel volumes in the high-dose region were measured using orthogonal barium films for 203 patients treated for rectal carcinoma with pelvic postoperative radiotherapy to 50 Gy in an EORTC multicentric study.

Results: The 5-year estimate of late pelvic small bowel obstruction requiring surgery was 11%.

Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma.

This paper describes the results of radiotherapy in early stage orbital non-Hodgkin's lymphoma. From 1970 to 1985, 33 orbital localizations in 30 patients were treated. The total dose applied ranged from 21 to 57 Gy (2 Gy per fraction), two-thirds of all patients received a dose of 40 Gy.

Dose-volume correlation in radiation-related late small-bowel complications: a clinical study.

The effects of the volume of irradiated small bowel on late small-bowel tolerance was studied, taking into account the equivalent total dose and type of pre-irradiation surgical procedure. A method was developed to estimate small-bowel volumes in the high-dose region of the radiation treatment using CT-scans in the treatment position. Using this method small-bowel volumes were measured for three-field and AP-PA pelvic treatments (165 cm3 and 400 cm3, respectively), extended AP-PA pelvic treatment (790 cm3), AP-PA treatment of para-aortic nodes (550 cm3) and AP-PA treatment of para-aortic and iliac nodes (1000 cm3).