Publications by authors named "Letizia Cattaneo"
Article Synopsis
- Thymic epithelial tumors (TETs) are rare tumors often linked to immune issues, like Good's syndrome (GS), which increases mortality risk from infections.
- The study reviewed COVID-19 incidence and severity among TET patients from March 2020 to April 2023, noting that about 66% of participants contracted COVID-19, regardless of GS presence.
- Results showed a significant correlation between GS and increased COVID-19 severity, with 45% of GS patients experiencing higher severity scores compared to just 7.7% in patients without GS.
Article Synopsis
- Spondylodiscitis is a rare condition with limited treatment options, requiring long-term therapy, typically lasting up to twelve months, and azoles are the only available oral treatment for home therapy.
- The case study reports a 68-year-old paraplegic patient who experienced reduced efficacy from azole treatment and was successfully treated with 200 mg of rezafungin weekly for 26 weeks after unsatisfactory results with voriconazole and liposomal amphotericin B.
- Rezafungin demonstrates a promising alternative for treating Candida-related osteomyelitis, especially in cases where standard therapies fail or are poorly tolerated, with the patient showing full recovery without side effects.
Background: Morbidity and mortality are higher in immunocompromised patients affected by COVID-19 than in the general population. Some authors have successfully used antiviral combination, but never in the early phase of the infection.
Methods: We conducted a retrospective cohort study to determine the efficacy and safety of the combination of two antivirals, with and without a monoclonal antibody (mAb), in both the early (within 10 days of symptoms) and in a later phase (after 10 days) of SARS-CoV-2 infection in immunocompromised patients admitted to our Facility.
Article Synopsis
- The intestinal microbiota is crucial for maintaining overall health and can influence various diseases, including chronic liver conditions like those caused by the Hepatitis C virus (HCV).
- Recent advancements in antiviral treatments, specifically direct-acting antiviral agents (DAAs), have led to a high success rate in clearing HCV infections (around 95%).
- A study involving 12 patients treated with DAAs revealed a decrease in harmful gut bacteria and an increase in microbial diversity after treatment, especially notable in patients without advanced liver cirrhosis.
Invasive fungal infections (IFIs) represent a severe complication of COVID-19, yet they are under-estimated. We conducted a retrospective analysis including all the COVID-19 patients admitted to the Infectious Diseases Unit of the Federico II University Hospital of Naples until the 1 July 2021. Among 409 patients, we reported seven cases of IFIs by Candida spp.
View Article and Find Full Text PDFWe evaluated the role of CRP and other laboratory parameters in predicting the worsening of clinical conditions during hospitalization, ICU admission, and fatal outcome among patients with COVID-19. Consecutive adult inpatients with SARS-CoV-2 infection and respiratory symptoms treated in three different COVID centres were enrolled, and they were tested for laboratory parameters within 48 h from admission. Three-hundred ninety patients were enrolled.
View Article and Find Full Text PDFChanging epidemiology of patients treated with direct acting antivirals for HCV and persistently high SVR12 in an endemic area for HCV infection in Italy: real-life 'LIver Network Activity' (LINA) cohort update results.
Expert Rev Gastroenterol Hepatol
September 2021
Background: Second generation direct acting antivirals (DAAs) drastically changed the landscape of chronic HCV (CHCV). Aim of this paper was to assess the effectiveness of DAAs, also looking at the demographic characteristics of subjects enrolled.
Research Design And Methods: Ambispective multi-center real-life study conducted among patients with CHCV treated with DAAs in Campania Region (Southern Italy).
Cystic echinococcosis (CE) is one of the neglected tropical diseases recognized by the WHO. affects more than 1 million people worldwide and is responsible for high costs in the healthcare system. A clear knowledge of the prevalence of CE and its clinical characteristics could have an important impact on the approach to its diagnosis and to the public health planning of treatment and control interventions.
View Article and Find Full Text PDFCystic echinococcosis (CE) is a zoonosis caused by the larval stage of the tapeworm . In humans, the infection induces the formation of parasitic cysts mostly in the liver and lungs, but virtually any organ can be affected. CE of the bone is one of the rarest forms of the disease, yet it is also extremely debilitating for patients and hard to manage for clinicians.
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