Publications by authors named "Letitia Graves"

Aim: To map the 2021 American Association of Colleges of Nursing Essentials to the American Nurses Association Essentials of Genomic Nursing for all nurses and provide resources for nursing faculty to support the seamless integration of genomics into existing undergraduate curricula.

Background: Since the completion of the Human Genome Project in 2003, rapid advancements in genomic science leading to practical applications of genomics have revolutionized all areas of healthcare. Nursing is built on foundational life sciences, including genomics.

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Background: Cancer-related cognitive impairment (CRCI) is a prevalent condition that significantly impacts the quality of life of individuals who receive cancer treatment. Clinical management of CRCI presents challenges due to the absence of a standardized assessment. This study identified clinically relevant phenotypic clusters of CRCI based on subjective and objective cognitive function scores.

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The major populations at risk for developing pressure ulcers are older adults who have multiple risk factors that increase their vulnerability, people who are critically ill and those with spinal cord injury/disease. The reported prevalence of pressure ulcers in the United States is 2.5 million.

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Background: Epigenetics studies the impact of environmental and behavioral factors on stable phenotypic changes; however, the state of the science examining epigenomic mechanisms of regulation related to secondary health conditions (SHCs) and neuroepigenetics in chronic spinal cord injury (SCI) remain markedly underdeveloped.

Objective: This scoping review seeks to understand the state of the science in epigenetics and secondary complications following SCI.

Methods: A literature search was conducted, yielding 277 articles.

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Article Synopsis
  • - The study aimed to identify genetic biomarkers linked to the risk of recurrent pressure injuries (PIs) in individuals with spinal cord injuries (SCI), focusing on veterans receiving care at specialized centers.
  • - Researchers conducted thorough assessments over several years, analyzing blood samples and health records to explore genetic variations and their connection to PI history, specifically identifying 260 genes related to fat metabolism and biological processes.
  • - Findings suggest that integrating genomic data with electronic health records could enhance the management of complex health issues like PIs in SCI patients, potentially enabling better-targeted care for higher-risk individuals.
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Background: The National Institute of Nursing Research developed the National Institutes of Health symptom science model (SSM) in 2015 as a parsimonious conceptual model to guide symptom science research.

Objectives: This concept development paper synthesizes justifications to strengthen the original model.

Methods: A literature review was performed, discussions with symptom science content expert stakeholders were held, and opportunities for expanding the current model were identified.

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Introduction: Fatigue is a prevalent and potentially debilitating symptom that impacts the health-related quality-of-life of individuals diagnosed with acute and chronic medical conditions. Yet, its etiologic mechanism is not fully understood. Additionally, the assessment and determination of the clinical meaning of fatigue and its multidimensionality may vary by medical condition.

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Purpose: The Doctor of Nursing Practice (DNP) programs have grown exponentially for the last 10 years across the United States. However, the intra-professional collaboration among DNP and PhD scholars is not clearly demonstrated in the literature as it relates to frequency, training models, and the outcomes of these collaborations on translation. The purposes of this paper are to: (1) examine the role for DNP nurses in symptom science research and (2) describe training models to cultivate the PhD-DNP collaboration to strengthen the translation of discoveries from nursing research, to facilitate implementation of discoveries, and to improve clinical practice of nurses.

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Article Synopsis
  • Incorporating biological data into symptom science helps to better understand common symptoms found in chronic conditions, like pain and fatigue.
  • A literature review identified eight functional genetic polymorphisms in seven genes linked to multiple symptoms, which could enhance symptom research.
  • Including these genetic polymorphisms could improve precision health by identifying those at risk for severe symptoms and guiding the development of targeted symptom management strategies.
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