Publications by authors named "Leticia Tarilonte"
The TAPR locus containing the TIM gene family is implicated in the development of atopic inflammation in mouse, and TIM-1 allelic variation has been associated with the incidence of atopy in human patient populations. In this study, we show that manipulation of the TIM-1 pathway influences airway inflammation and pathology. Anti-TIM-1 mAbs recognizing distinct epitopes differentially modulated OVA-induced lung inflammation in the mouse.
View Article and Find Full Text PDFThe development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells. How effector T cell responses are regulated once these cell populations are established remains unclear. The recently described T cell and airway phenotype regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically associated with Th2 cytokine production and Th2-dependent immune responses.
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- TWEAK is a member of the TNF family that induces proinflammatory cytokines in synovial fibroblasts from rheumatoid arthritis patients, and its levels rise significantly during collagen-induced arthritis in mice.
- Blocking TWEAK with a neutralizing antibody reduced inflammation and joint damage, proving effective if administered before disease onset but not during the early phases.
- The study suggests that targeting the TWEAK/Fn14 pathway could serve as a new therapeutic approach for rheumatoid arthritis by aiding joint tissue repair and reducing inflammation.