Adjuvant Pam3CSk4 does not improve the immunization against infection in C57BL/6 mice.

Background: Cryptococcosis is a relevant invasive fungal infection that affects immunocompromised and immunocompetent individuals when caused by . Host innate and adaptive immune responses can be subverted by that blocks the differentiation of T helper (Th) 1 and Th17 cells, which are involved in the protection against cryptococcosis. Moreover, the macrophage polarization is modulated by infection that requires a balance in the macrophage subsets to control the infection.

Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity.

Ethnopharmacological Relevance: Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, anti-inflammatory, and antimicrobial.

Aim Of The Study: To characterize the phytochemical profile of the hydromethanolic extract obtained from B. fagifolia leaves (BF extract) and to evaluate the toxicity and the antifungal activity.

Adjuvant Curdlan Contributes to Immunization against Infection in a Mouse Strain-Specific Manner.

The low efficacy and side effects associated with antifungal agents have highlighted the importance of developing immunotherapeutic approaches to treat infection. We developed an immunization strategy that uses selective Dectin-1 agonist as an adjuvant. BALB/c or C57BL/6 mice received curdlan or β-glucan peptide (BGP) before immunization with heat-killed , and the mice were infected with viable on day 14 post immunization and euthanized 14 days after infection.