Publications by authors named "Leticia Rodrigues Sampaio"
Role of the STING pathway in myeloid neoplasms: a prospero-registered systematic review of principal hurdles of STING on the road to the clinical practice.
Leticia Rodrigues Sampaio Ricardo Dyllan Barbosa Dias João Vitor Caetano Goes Renata Pinheiro Martins de Melo Daniela de Paula Borges
Med Oncol
April 2024
Article Synopsis
- * The STING pathway, which triggers an immune response by recognizing DNA fragments in cells, may have implications in cancer, but its specific role in myeloid neoplasms remains unclear and needs further exploration.
- * A systematic review indicates that while there is potential for STING as a therapeutic target when used alongside current treatments, more high-quality research and clinical trials are essential for understanding its impact on myeloid cancers.
Article Synopsis
- * Significant downregulation of SIRT2-7 was observed in MDS patients, but some genes, like SIRT4, showed increased expression in patients aged 60+, while SIRT2 and SIRT3 were upregulated in those with severe anemia and chromosomal abnormalities.
- * The study highlights the potential significance of SIRTs in MDS development and progression, suggesting they could be important therapeutic targets and offering avenues for future research focused on managing
Article Synopsis
- - The study investigates the role of immune checkpoint PD-L1 in Myelodysplastic Syndromes (MDS), a bone marrow disorder linked to genetic and immune issues, and its potential impact on tumor growth and prognosis.
- - Results show that patients with dyserythropoiesis have higher PD-L1 expression, and those with MDS-EB2 exhibit significant upregulation compared to MDS-EB1, suggesting a correlation between PD-L1 levels and disease severity.
- - The findings indicate that elevated PD-L1 expression may lead to poorer outcomes in MDS patients, highlighting the need for further research on anti-PD-L1 therapies for high-risk cases.
Toll-like receptors are mutated or overexpressed in up to 50% of patients with myelodysplastic syndrome (MDS). Endogenous retroviruses (ERV) trigger TLR3 leading to interferon regulatory genes (IRFs) activation. We evaluated if the ERVs-TLR3-IRF axis activation would be linked to MDS pathogenesis and we also conducted a detailed cancer analysis of the ERVs, TLR3 and IRFs gene expression in 30 cancer types using GEPIA database.
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