Publications by authors named "Leticia O Lopes"
Coronavirus disease 2019 (COVID-19) presents a wide spectrum of symptoms, the causes of which remain poorly understood. This study explored the associations between autoantibodies (AABs), particularly those targeting G protein-coupled receptors (GPCRs) and renin‒angiotensin system (RAS) molecules, and the clinical manifestations of COVID-19. Using a cross-sectional analysis of 244 individuals, we applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms.
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- MicroRNAs play a key role in regulating gene expression, with muscle-specific miRNAs influencing muscle characteristics and responses.
- miR-155 is linked to muscular dystrophy and muscle atrophy but its exact functions and targets in these conditions are not fully understood.
- This study identifies that miR-155-5p alters the expression of 359 genes in muscle cells, affecting pathways related to metabolism, cell cycle, muscle maintenance, and immune response, particularly increasing M2 macrophages in dystrophic muscles.
Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs (miRNAs) in muscle wasting involves the regulation of thousands of target transcripts. However, the miRNA-target networks associated with IL6-induced muscle atrophy remain to be characterized.
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