Clinicopathological comparison and cytokeratin-10 expression between Lichen planus and oral lichenoid lesions.

Objectives: This study aimed to compare clinicopathological features and immunostaining for cytokeratin-10 between oral lichen planus and oral lichenoid lesions.

Design: This was a retrospective longitudinal study comparing lichen planus and oral lichenoid lesions diagnosed at the Oral Pathological Anatomy Service that analyzed sociodemographic and clinicopathological data and CK10 expression. Chi-square tests, Fisher's exact tests and Mann-Whitney tests or Student's t tests were used when appropriate, and p values < 0.

Fibrosis in Oral Carcinoma and Leukoplakia: an Immunohistochemical Study.

Objectives: The objective of this retrospective study was to evaluate clinicopathologic profile and collagen type I expression in oral leukoplakia and oral squamous cell carcinoma to elucidate stromal alterations in malignant transformation.

Material And Methods: The sample consisted of 40 cases, of which 20 oral leukoplakia (OL) were classified according to World Health Organization and binary systems for grading oral epithelial dysplasia (OED) as well as 20 oral squamous cell carcinoma (OSCC), moderately or poorly differentiated. Type I collagen was analysed by immunohistochemistry, Fisher's exact test and chi-square test evaluated the clinical data.

How malocclusion interferes with tissue inhibitor of metalloproteinase-1 expression and morphology of the articular cartilage of the mandible in female rats.

Objective: The purpose of this study was to investigate morphological alterations and tissue inhibitor of metalloproteinase-1 expression in the articular cartilage of the mandible under conditions of experimentally induced malocclusion.

Design: Twenty-four 8-week-old female Wistar rats were used and divided into control and experimental groups with two different treatment periods (2 and 4 weeks). Sagittal malocclusions were orthodontically created, causing mesial movement of the first molars and distalization of the third molars unilaterally and on opposite sides of the arches.

Subacute high-refined carbohydrate diet leads to abnormal reproductive control of the hypothalamic-pituitary axis in female rats.

We previously reported that female rats placed on a diet containing refined carbohydrates (HCD) resulted in obesity and reproductive abnormalities, such as high serum LH concentration and abnormal ovarian function. However, the impacts at the hypothalamic-pituitary (HP) function, specifically regarding pathways linked to reproductive axis modulation are unknown. In this study, we assessed whether subacute feeding with HCD results in abnormal reproductive control in the HP axis.

Fibrosis as a Risk Factor for Cutaneous Squamous Cell Carcinoma in Recessive Dystrophic Epidermolysis Bullosa: A Systematic Review.

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe subtype of epidermolysis bullosa caused by changes in collagen VII with a high risk of early development of cutaneous squamous cell carcinoma (cSCC). This review aimed to discuss the relationship between the recurrent healing process, the appearance of fibrosis, and malignant epithelial transformation in RDEB. We searched PubMed, the Regional Portal of the Virtual Health Library, and Embase for articles on the relationship between blistering, recurrent scarring, and fibrosis in the context of cSCC and RDEB.

Epidermolysis bullosa in oral health: clinical manifestations and salivary alterations.

Unlabelled: Epidermolysis bullosa (EB) is an inherited disease characterized by the fragility of the skin and mucous membranes. All types/subtypes of EB can lead to alterations in the mouth and glands.

Objective: To evaluate clinical manifestations of EB on the oral mucosa and alterations in salivary flow.

Immunohistochemical Study of Laminin-332 γ2 Chain and MMP-9 in High Risk of Malignant Transformation Oral Lesions and OSCC.

Objectives: Oral squamous cell carcinoma is associated with alterations in basement membrane. Laminin-332 is present in basal lamina and performs multiple biologic effects by γ2 chain. Matrix metalloproteinase acts disrupting extracellular components and was related to poor prognosis in cancer.

Fibrosis and Mast Cells in Colorectal Lesions: Significance in Adenoma-Colorectal Cancer Sequence and Association with Diet.

Purpose: Adenoma is the most common benign neoplasm with potential to progress into colorectal cancer (CRC), a disease responsible for high rates of mortality. However, it is not possible yet to establish which lesions will evolve into CRC. We aimed to investigate the intrinsic factors, diet profile, and microenvironment as factors involved in adenoma-CRC progression.