Sex steroid hormones, leptin, and high-sensitivity C-reactive protein levels in adolescents.

Background: The association of sex hormones with C-reactive protein (CRP) levels has been reported. However, this association remains unexplored in children in whom important anthropometric and hormonal changes are taking place.

Objectives: To analyze the association between high-sensitivity CRP (hs-CRP) and testosterone, estradiol and sex hormone-binding globulin (SHBG) levels in a population-based sample of adolescents, and to evaluate the influence of leptin levels on this association.

Opposite Association of Adropin Concentrations with Obesity in Prepubertal Children Compared with Adolescents.

Objective: The aim of this study was to evaluate the association between obesity and plasma adropin levels in two cohorts of children at two different ages.

Methods: Adropin concentrations were measured in 71 prepubertal and 41 pubertal children with obesity and their age- and sex-matched normal weight counterparts (69 prepubertal and 42 pubertal children). Information was available in these children on insulin levels, lipid profile, and leptin levels.

Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group.

Introduction: Our objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables.

Research Design And Methods: We conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity.

Sex-specific association of plasma nesfatin-1 concentrations with obesity in children.

Background: Nesfatin-1, an anorexigenic peptide, has been associated with food intake and thermogenesis, with discordant findings in humans and scarce studies in children to date.

Objectives: The aim of this study was to analyze the relationship of obesity with nesfatin-1 levels in two cohorts of children.

Methods: Plasma nesfatin-1 concentrations were analyzed in 6- to 9-year-olds (n = 140) and 12- to 16-year-old children (n = 96), including children with obesity and their sex- and age-matched normal-weight counterparts.

Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children.

The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children.