Publications by authors named "Leticia Hayes"
Regional neuron loss following stroke can result in remote brain changes due to diaschisis and secondary brain atrophy. Whole brain changes post-stroke can be captured by the predicted brain age difference (brain-PAD), a neuroimaging-derived biomarker of global brain health previously associated with poorer chronic stroke outcomes. We hypothesized that greater lesion damage would be longitudinally associated with worsening brain-PAD during subacute stroke, and conversely, that poorer baseline brain-PAD would be associated with enlarged lesion damage.
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- After a stroke affecting the corticospinal tract (CST), individuals often experience motor deficits in their upper extremities, such as decreased muscle strength and control.
- This study compared 15 stroke patients to 28 healthy individuals, focusing on how the ipsilesional CST and contralesional corticoreticulospinal tract (CReST) relate to motor behaviors in the paretic (weakened) arm.
- Findings indicated that stronger ipsilesional CST projections improved motor control, while stronger contralesional CReST projections improved muscle strength, suggesting their complementary roles in recovery, regardless of whether deficits were in the arm or hand.
Unlabelled: After corticospinal tract (CST) stroke, several motor deficits in the upper extremity (UE) emerge, including diminished muscle strength, motor control, and muscle individuation. Both the ipsilesional CST and contralesional corticoreticulospinal tract (CReST) innervate the paretic UE and may have different innervation patterns for the proximal and distal UE segments. These patterns may underpin distinct pathway relationships to separable motor behaviors.
View Article and Find Full Text PDFObjective: To determine if the distribution of transcallosal inhibition (TI) acting on proximal and distal upper extremity muscles is altered in chronic stroke.
Methods: We examined thirteen healthy controls and sixteen mildly to moderately impaired chronic stroke patients. We used transcranial magnetic stimulation (TMS) to probe TI from the contralesional onto ipsilesional hemisphere (assigned in controls).