Publications by authors named "Leticia Garea Sanchez"
Oncotarget
September 2017
Article Synopsis
- Carboxypeptidase E (CPE), a multifunctional protein, influences tumor behavior in glioblastoma (GBM) by affecting cell migration, proliferation, and survival.*
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- In this study, researchers found that secreted CPE (sCPE) activates mTORC1 signaling and reduces GBM cell migration by negatively regulating Rac1 signaling, with knockdown of CPE leading to increased cell motility.*
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- Additionally, sCPE enhances glucose metabolism by promoting its entry into the tricarboxylic acid cycle while reducing lactate production, contributing to a less invasive nature of tumor cells and revealing the link between tumor invasion and metabolic changes.*
