Publications by authors named "Leticia Cortes Espinosa"
Introduction: Sporadic Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology. In recent years, it has been established that a genetic component underlies different forms of the disease. For instance, mitochondrial genome variants have been implicated in the pathogenesis of the PD.
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- The study aimed to investigate the relationship between specific genetic polymorphisms (VDR and ESR1) and bone mineral density (BMD) in postmenopausal Mexican-mestizo women.
- Results indicated that the ESR1 polymorphism rs9340799 and a specific haplotype of ESR1 were significantly linked to variations in BMD at the femoral neck, while the other examined polymorphisms showed no significant impact.
- The findings suggest that certain genetic factors may play a crucial role in influencing bone health in this demographic group, particularly after accounting for other variables.
Osteoporosis is characterized by low bone mineral density (BMD). One of the most important factors that influence BMD is the genetic contribution. The collagen type 1 alpha 1 (COL1A1) and the JAGGED (JAG1) have been investigated in relation to BMD.
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- This study examines the relationship between genetic variations in the TNFRSF11B gene and bone mineral density (BMD) in postmenopausal Mexican Mestizo women.
- A total of 750 women participated, with BMD assessed at the hip and lumbar spine, while three specific single-nucleotide polymorphisms (SNPs) were analyzed.
- The research found that while individual SNPs did not show significant differences, a specific haplotype (A-G-T) was linked to variations in femoral neck BMD, suggesting haplotypes may serve as better genetic markers for BMD variations.
Objective: Considering that the Mexican mestizo population seems to be the result of a genetic admixture, we proposed that further research is needed to evaluate the role of ethnicity in conjunction with health-related factors to better understand ethnic differences in bone mineral density (BMD). The aim of this study was to analyze several risk factors related to the development of osteoporosis in postmenopausal Mexican mestizo women.
Methods: We included 567 postmenopausal Mexican mestizo women.