Publications by authors named "Leticia Camargo Tavares"
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance.
View Article and Find Full Text PDFConstipation is associated with an increased risk of major adverse cardiac events in a UK population.
Am J Physiol Heart Circ Physiol
October 2024
Article Synopsis
- Traditional cardiovascular risk factors like hypertension don’t fully explain the occurrence of major adverse cardiac events (MACEs), indicating the need to explore additional risk factors.
- The study investigates the link between constipation and MACE using data from the UK Biobank, revealing that individuals with constipation have a significantly higher risk of developing conditions like heart failure, ischemic stroke, and acute coronary syndrome.
- Positive genetic correlations were found between constipation and these MACE subgroups, suggesting that constipation may be an underestimated risk factor for cardiovascular diseases, prompting the need for more research into its implications and underlying mechanisms.
Background & Aims: Irritable bowel syndrome (IBS) shows genetic predisposition, and large-scale genome-wide association studies (GWAS) are emerging, based on heterogeneous disease definitions. We investigated the genetic architecture of IBS defined according to gold standard Rome Criteria.
Methods: We conducted GWAS meta-analyses of Rome III IBS and its subtypes in 24,735 IBS cases and 77,149 asymptomatic control subjects from 2 independent European cohorts (UK Biobank and Lifelines).
Article Synopsis
- Microscopic colitis (MC) includes two subtypes: collagenous colitis (CC) and lymphocytic colitis (LC), and their relationship as either distinct entities or a continuum needs further investigation.
- A genome-wide association study (GWAS) involving nearly 15,000 individuals found a strong link between HLA alleles and collagenous colitis, highlighting specific alleles and their variants as significant factors.
- The findings suggest that CC and LC have different biological mechanisms, particularly with HLA's relevant role in CC, which raises questions about current definitions and classifications of microscopic colitis.
A pilot genome-wide association study meta-analysis of gastroparesis.
United European Gastroenterol J
October 2023
Article Synopsis
- Gastroparesis (GP) is a condition marked by delayed gastric emptying, and this study aimed to investigate the genetic factors contributing to it using a genome-wide association study (GWAS).
- The research involved comparing genetic data from 880 GP patients and over 58,000 controls, leading to the identification of nine genomic loci that showed suggestive associations with GP, particularly focusing on immune and motor dysregulation pathways.
- Notably, the gene PXDNL was linked to increased abdominal pain severity in GP patients, suggesting a possible target for future research on GP treatments.
Populations used to create warfarin dose prediction algorithms largely lacked participants reporting Hispanic or Latino ethnicity. While previous research suggests nonlinear modeling improves warfarin dose prediction, this research has mainly focused on populations with primarily European ancestry. We compare the accuracy of stable warfarin dose prediction using linear and nonlinear machine learning models in a large cohort enriched for US Latinos and Latin Americans (ULLA).
View Article and Find Full Text PDFWe conducted a multi-site investigation of genetic determinants of warfarin dose variability in Latinos from the U.S. and Brazil.
View Article and Find Full Text PDFEvaluation of the Long-Term Impact on Quality After the End of Pharmacist-Driven Warfarin Therapy Management in Patients With Poor Quality of Anticoagulation Therapy.
Front Pharmacol
July 2020
Background: Warfarin is the most common oral anticoagulant drug, especially in low-income and emerging countries, because of the high cost of direct oral anticoagulant (DOACs), or when warfarin is the only proven therapy (mechanical prosthetic valve and kidney dysfunction). The quality of warfarin therapy is directly associated with dose management. Evidence shows that pharmaceutical care achieves a better quality of therapy with warfarin.
View Article and Find Full Text PDFThromboembolic events are associated with high mortality and morbidity indexes. In this context, warfarin is the most widely prescribed oral anticoagulant agent for preventing and treating these events. This medication has a narrow therapeutic range and, consequently, patients usually have difficulty in achieving and maintaining stable target therapeutics.
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