Publications by authors named "Letian Mei"
Article Synopsis
- The study investigated the effects of sinomenine hydrochloride (SH) on colitis induced by DSS in mice, focusing on the Notch signaling pathway.
- Mice were divided into four groups and assessed for disease activity, mucosal injury, and histopathological changes, revealing that SH significantly alleviated colitis symptoms and reduced inflammation markers.
- Results indicated that SH treatment lowered the expression of key proteins in the Notch signaling pathway and reduced pro-inflammatory cytokines, suggesting that its therapeutic effect is linked to inhibiting Notch pathway overactivation.
Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the TLR2/NF-κB signaling pathway.
Clin Res Hepatol Gastroenterol
August 2024
Background: Sinomenine hydrochloride (SH) has anti-inflammatory and immunosuppressive effects, and its effectiveness in inflammatory diseases, such as rheumatoid arthritis, has been demonstrated. However, whether SH has a therapeutic effect on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice and its mechanism of action have not been clarified. This study aimed to investigate the therapeutic effects and mechanism of action of SH on UC.
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