Publications by authors named "Lethiec F"

Article Synopsis
  • The COVID-19 pandemic sparked a massive research effort in academia and industry, although some of it was redundant and poorly coordinated on national and international levels.
  • Regulatory changes and the digitization of processes helped make clinical trials more accessible to patients, particularly in the UK where a single platform trial optimized resource use.
  • Despite highlighting weaknesses in France's clinical research organization, such as funding issues and data sharing reluctance, the crisis demonstrated the adaptability of stakeholders and improved processes for future therapeutic innovations.
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The French Cancer Plan 2003-2007 has made translational research central to its research programme, to ensure the care-research continuum and the quickest application possible for the most recent discoveries, for the patients' benefit. This is a new field of research, still little-known or ill-understood. A working group, composed of physicians and researchers from academic research and industrial research, sought to define translational research in cancerology and define the issues at stake in it.

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PHYML Online is a web interface to PHYML, a software that implements a fast and accurate heuristic for estimating maximum likelihood phylogenies from DNA and protein sequences. This tool provides the user with a number of options, e.g.

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MaM is a software tool that processes and manipulates multiple alignments of genomic sequence. MaM computes the exact location of common repeat elements, exons and unique regions within aligned genomics sequences using a variety of user identified programs, databases and/or tables. The program can extract subalignments, corresponding to these various regions of DNA to be analyzed independently or in conjunction with other elements of genomic DNA.

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