Introduction: Whipple disease is a rare systemic infection caused by Tropheryma whippelii that usually manifests with joint pain, weight loss, diarrhoea and abdominal pain. However, in some cases the infection may involve other organs and tissues.
Case Presentation: We report on a 44-year-old man with Whipple disease which led to renal amyloidosis and end-stage renal failure.