Rosuvastatin positively changes nerve electrophysiology in diabetic rats.

Objective: To examine the effect of rosuvastatin on peripheral nerve function in diabetic rats using electrophysiological measurements.

Background: Diabetes was induced in 5-day-old male Wistar rats by intraperitoneal (i.p.

Capillary endothelial but not lymphatic function is restored under rosiglitazone in Zucker diabetic fatty rats.

If thiazolidinediones have shown beneficial effects on macrovascular endothelial function, their effects on microcirculation and lymphatic function are not well documented. The aim of the study was to assess the effect of rosiglitazone on interstitial albumin retention and lymphatic function in Zucker Diabetic Fatty (ZDF) rats. Three series of 9-14 rats were studied: Lean (fa/?) controls, ZDF (Gmi-fa/fa) rats and ZDF rats treated with rosiglitazone from 8 to 26 weeks of age (ZDF-ROSI).

Nerve electrophysiological changes in rats with early induced diabetes.

In rats with diabetes induced at weaning, pathological examinations have shown that the reduction of myelin thickness occurs earlier than axon size reduction. The aim of this study was to provide a detailed description of neurophysiological changes during nerve growth and maturation in rats with streptozotocin-induced diabetes in prepubertal stage. Five-day male Wistar rats received an injection of streptozotocin.

Effect of rosuvastatin on capillary filtration of albumin and blood pressure in rats with streptozotocin-induced diabetes.

An increase in capillary filtration of albumin (CFA) is well demonstrated in diabetes. Statins may exert a protective effect against endothelial dysfunction. The aim of this study was to test whether rosuvastatin may prevent the increase in peripheral CFA in diabetic rats and the role of blood pressure lowering.

Effect of cerivastatin on peripheral capillary permeability to albumin and peripheral nerve function in diabetic rats.

Objective: To examine the effect of cerivastatin on capillary permeability to albumin and peripheral nerve function in diabetic rats.

Animals: Diabetes was induced in male Wistar rats by i.p.

Motor and sensory conduction velocities and amplitude of nerve or muscle potentials in the normal rat according to age.

The relative changes in sensory and motor nerve conductions and SNAP and CMAP amplitudes were studied on the sural and tibial posterior nerves in anesthetized male rats, between the 1st and the 23rd month. Neural growth was controlled with the measure of the nerve path length on the skin, between stimulating and recording cathodes for the sural nerve and proximal and distal stimulating cathodes for the tibial posterior nerve. The sural SCV and SNAP amplitude are consistent with a more accurate method than the H-reflex one.

In vivo sequential study of skeletal muscle capillary permeability in diabetic rats: effect of anthocyanosides.

Alterations in the capillary filtration of macromolecules are well documented in diabetic patients and experimental diabetes. Various flavonoids including anthocyanosides and ginkgo biloba extracts have been shown to be effective against experimentally induced capillary hyperfiltration. The aim of the present study was to test the effects of anthocyanosides on capillary filtration in diabetic rats.

In vitro model of far-field stationary potentials: boundary effects on propagated potentials.

Far-field stationary potentials have been said to result from several factors such as changes in the anatomical orientation of the direction of a propagating nerve action potential (AP) or local modifications of the impedance in the external volume conductor by changes in its geometry or resistivity. In the case of an impedance variation due to the presence of boundaries in the geometry of the medium, the findings reported in this paper showed that it is possible to record simultaneously AP and stationary potentials which we have called boundary potentials (BPs). The BP amplitude depended on the number of active axons at the boundary, on the distance between the boundary and one of the recording electrodes, and on the local impedance variation.