Management of newly diagnosed non-insulin-dependent diabetes mellitus in the primary care setting: effects of 2 years of gliclazide treatment--the Diadem Study.

Five thousand five hundred seventy-two newly diagnosed non-insulin-dependent diabetes mellitus (NIDDM) patients (3,225 men and 2,347 women; mean age, 58.5 years) were recruited through the General Practitioners (GPs) network in France. All had persistent hyperglycemia after a preliminary 3-month period with dietary and life-style modification.

[Cardiovascular risk factors in type 2 diabetes].

Morbidity and mortality through coronary atherosclerosis are higher in Type 2 diabetic patients than in nondiabetic subjects, roughly by a factor of 2 in males and 3 in females. Methodological problems in attempting to weigh the relative effects of each factor make it difficult to accurately interpret the numerous epidemiological data already available. Three issues are discussed here:--Do diabetics have more "classic" risk factors than nondiabetics? The incidence of hypertension, lipid disorders, and even smoking is practically consistently higher in diabetics, with "diabetic" lipid disorders (decreased HDL cholesterol and hypertriglyceridemia) topping the list.

[Therapeutic and economic aspects of dracunculosis in a Parisian hospital].

We studied 18 cases of dracunculosis treated in our department of Internal Medicine in Paris. The mean duration of the hospital stay is 38 days (15 to 90). The cost of this stay, calculated on the basis of the daily charge, accounts for 93.

[Hypoglycemic and microvascular properties of gliclazide: a review of the latest international studies].

The effects of gliclazide on blood sugar levels and the micro-vascular system have been specified by the latest international studies of this antidiabetic agent presented at the 11th World Congress on Diabetes Mellitus. The potency of gliclazide is similar to that of the most effective reference agents. However, the mode of action of gliclazide, which induces an insulin release resembling physiologic conditions, explains why hypoglycemia is uncommon.

[Two cases of pentastomiasis observed in Paris (author's transl)].

The observations of two black African patients seen among 940 hospitalized patients are reported. Intraabdominal calcified larvas, probably of Porocephalus (Armillifer) armillatus were found in both patients. The cycle of this Pentostomida is recalled.

[152 cases of tuberculosis in African Negro immigrants in a Parisian service of internal medicine (author's transl)].

This study of 152 cases of tuberculosis in African Negro immigrants seen between 1972 and 1976 showed the predominance of especially pulmonary respiratory lesions and/or hilar ganglio-mediastinal lesions. The other lesions are frequent, i.e.

[Osseous manifestations of treponematoses : six cases in immigrated black African (author's transl)].

The authors report the cases of six immigrated Black Africans with clinical and radiological (4 cases with condensing osteitis ; 2 cases with condensing forms and multiple lacunae) bone manifestations ; these manifestations, the serological tests and the osseous biopsy (three cases out of four) are consistent with the diagnosis of bone syphilis. These facts are discussed and ascribed to tertiary syphilis rather than to congenital or secondary syphilis, to yaws or endemic syphilis.

[Osseous manifestations and hemoglobinopathies C (author's transl)].

The authors report two cases of hemoglobin C trait and hemoglobin C disease with bone tuberculosis and, in the first case, bone infarction of one condyle two years after the tuberculosis of the other knee. This suggests the possibility of osseous manifestations in the course of hemoglobin C trait or hemoglobin C disease apart from hemoglobin SC disease.

[One hundred and twenty-three cases of sickle-cell trait (author's transl)].

One hundred and twenty-three cases of sickle-cell trait (122 negro immigrants) are studied in a department of internal medicine. The frequencies of G6PD deficiency, anemia, splenomegaly and tuberculosis are neighbouring at the negro without hemoglobinopathy. The relationship between the sickle-cell trait and the reason of admission of the final diagnosis il likely in 2,4 % of the cases, doubtfully in 15,4 %, null in the other cases.

[Precocious pseudo-puberty due to HCG-secreting androblastoma of the ovary. One case (author's transl)].

A case of ovarian androblastoma (arrhenoblastoma) of the intermediate differentiation type in a 5-year old girl is reported. The clinical features were precocious isosexual puberty with secondary masculinization. The tumour was removed but relapsed 26 months later, requiring ovariectomy and salpingectomy.

[Oltipraz as brief treatment of schistosomiasis (comparison with niridazole) (author's transl)].

161 patients affected by schistosomiasis due in most cases to S. haematobium, and less frequently to S. mansoni, received one day treatment with 4,5 g a day of oltipraz in a first group and, later on, 3 g a day in another group.