Publications by authors named "Lesly Torres-Gonzalez"
Myeloid cell leukemia 1 (MCL-1) is a member of the B-cell lymphoma 2 protein family and has anti-apoptotic functions. Deregulation of MCL-1 has been reported in several cancers, including lung and breast cancer. In the present study, the association of MCL-1 expression with molecular features in colorectal cancer (CRC) has been highlighted.
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- - Colorectal cancer (CRC) is a major cause of cancer deaths globally, with immune checkpoint inhibitors improving outcomes mainly in a small subset (10%) of cases that have specific genetic features.
- - The review discusses key tissue markers like KRAS and HER2, their impact on treatment resistance, and advances in targeted therapies, emphasizing the importance of predictive biomarkers for personalized treatment in CRC.
- - It also highlights the potential of liquid biopsies and summarizes current evidence while pointing out gaps in knowledge, aiming to improve the application of biomarkers in clinical practice for CRC patients.