Double dissociation in radial and rotational motion sensitivity.

Neurophysiological experiments have shown that a shared region of the primate visual system registers both radial and rotational motion. Radial and rotational motion also share computational features. Despite these neural and computational similarities, prior experiments have disrupted radial, but not rotational, motion sensitivity -a single dissociation.

Using differential scanning calorimetry for the development of non-reduced capillary electrophoresis sodium dodecyl sulfate methods for monoclonal antibodies.

Analysis of non-reduced and reduced monoclonal antibodies (mAbs) by capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) is routinely used to detect product size variants and process-related impurities. Levels of high molecular weight (HMW) forms obtained from this method usually trend comparably to those obtained by orthogonal methods such as size-exclusion ultra-high performance liquid chromatography (SE-UHPLC). However, in the presented case study, comparison of CE-SDS data for three IgG1 mAbs (trastuzumab, mAb1, and mAb2) showed a discrepancy between amounts of observed HMW forms in mAb2 compared with its native forms determined by SE-UHPLC (~17% vs.

Global depth perception alters local timing sensitivity.

Dynamic environments often contain features that change at slightly different times. Here we investigated how sensitivity to these slight timing differences depends on spatial relationships among stimuli. Stimuli comprised bilaterally presented plaid pairs that rotated, or radially expanded and contracted to simulate depth movement.

Superior Visual Timing Sensitivity in Auditory But Not Visual World Class Drum Corps Experts.

World class drum corps require cooperation among performance artists to render precisely synchronized and asynchronized events. For example, drum corps visual aesthetics often feature salient radial and rotational motion displays from the color guard. Accordingly, extensive color guard training might predict superior visual timing sensitivity to asynchronies in radial and rotational motion displays.

Visual speed sensitivity in the drum corps color guard.

Drum corps color guard experts spend years developing skills in spinning rifles, sabers, and flags. Their expertise provides a unique window into factors that govern sensitivity to the speed of rotational and radial motion. Prior neurophysiological research demonstrates that rotational and radial motion register in the Medial Superior Temporal (MST) region of the primate visual system.

Simultaneity and Temporal Order Judgments Exhibit Distinct Reaction Times and Training Effects.

A considerable body of sensory research has addressed the rules governing simultaneity judgments (SJs) and temporal order judgments (TOJs). In principle, neural events that register stimulus-arrival-time differences at an early sensory stage could set the limit on SJs and TOJs alike. Alternatively, distinct limits on SJs and TOJs could arise from task-specific neural events occurring after the stimulus-driven stage.

Left visual field attentional advantage in judging simultaneity and temporal order.

Dynamic environments often contain features that vary simultaneously as well as features that vary sequentially. In principle, the correspondingly distinct sensations of simultaneity and temporal order could arise from a single shared neural computation that involves differencing two arrival times. On the other hand, simultaneity judgments (SJs) and temporal order judgments (TOJs) have distinct informational requirements that could be optimized by distinct neural events.

Remapping time across space.

Multiple lines of evidence indicate that visual attention's temporal properties differ between the left and right visual fields (LVF and RVF). Notably, recent electroencephalograph recordings indicate that event-related potentials peak earlier for LVF than for RVF targets on bilateral-stream rapid serial visual presentation (RSVP) identification tasks. Might this hastened neural response render LVF targets perceptually available sooner than RVF targets? If so, how might the visual system reconcile these timing differences to estimate simultaneity across the LVF and RVF? We approached these questions by presenting bilateral-stream RSVP displays that contained opposite-hemifield targets and requiring participants to judge both the targets' temporal order and simultaneity.

Ambulatory care: a decade of evolution.

Leslie Welch, a director at HLM Architects, explains how new generation, well-equipped ambulatory and emergency care centres, a relatively new development in the UK, are offering local day care patients a holistic healthcare service in a high quality setting, while reducing pressure on general hospitals and cutting waiting times.