Publications by authors named "Leslie P Zuniga-Macias"
Article Synopsis
- Aguascalientes has a high rate of kidney failure in young adults, potentially linked to low kidney volume (KV) at birth and exposure to harmful substances (xenobiotics).
- The study involved 299 healthy pregnant women, analyzing their urine, amniotic fluid, and their newborns' urine to measure various toxic metals and pesticides, alongside calculating the total kidney volume.
- Results indicated that exposure to specific pesticides and fluoride during pregnancy correlated with low kidney volume in infants, suggesting a possible connection to kidney health issues and electrolyte imbalances.
Histologic characterization and risk factors for persistent albuminuria in adolescents in a region of highly prevalent end-stage renal failure of unknown origin.
Dulce M Macias Diaz Myriam Del Carmen Corrales Aguirre Ana Lilian Reza Escalera Maria Teresa Tiscareño Gutiérrez Itzel Ovalle Robles
Clin Kidney J
July 2022
Article Synopsis
- - The study investigates the high prevalence of end-stage renal failure of unknown origin (ESRD-UO) among adolescents in Aguascalientes, Mexico, particularly affecting 20-40 year-olds, by screening for chronic kidney disease (CKD) and identifying associated risk factors.
- - In analyzing 513 students, the research found that 3.7% exhibited persistent albuminuria, though there were no significant homeostatic or anatomical abnormalities detected through renal ultrasound; however, those with albuminuria did show reduced total renal volume.
- - Kidney biopsies revealed glomerulomegaly and various podocyte abnormalities, with identified risk factors linked to environmental exposures and family health history, while a higher BMI and breastfeeding appeared
Serpin-A3 is Associated with Persistent Albuminuria in Adolescents with Secondary Podocytopathy, in a Region with High Prevalence of Chronic Kidney Disease of Unknown Origin.
Leslie P Zúñiga-Macías Ricardo E Ramírez-Orozco Francisco J Avelar-González Rosalba Pérez-Villalva Norma A Bobadilla
Rev Invest Clin
May 2023
Background: The state of Aguascalientes, Mexico, has been recognized as a chronic kidney disease hotspot. Screening studies have revealed a high prevalence of persistent albuminuria (pA), histologically characterized by glomerulomegaly, and incomplete podocyte fusion, probably associated with oligonephrony. To date, urinary biomarkers have not been explored in this population.
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