Publications by authors named "Leslie M Walsh"
Article Synopsis
- Improved glioblastoma (GBM) therapies are needed, with a focus on evaluating LSD1 inhibitors in models that reflect patient tumor diversity and resistance.
- Researchers conducted RNA-seq to explore the effects of LSD1 knockdown and inhibition in patient-derived GBM stem cell lines and mouse models, leading to the identification of genes related to treatment resistance.
- Findings suggest that LSD1 inhibitors can delay tumor growth, and identifying resistance-associated genes may help develop more effective combination treatments in the future.
