Publications by authors named "Leslie M Sage"
Overexpression of VEGF165b in podocytes reduces glomerular permeability.
J Am Soc Nephrol
September 2010
The observation that therapeutic agents targeting vascular endothelial growth factor-A (VEGF-A) associate with renal toxicity suggests that VEGF plays a role in the maintenance of the glomerular filtration barrier. Alternative mRNA splicing produces the VEGF(xxx)b family, which consists of antiangiogenic peptides that reduce permeability and inhibit tumor growth; the contribution of these peptides to normal glomerular function is unknown. Here, we established and characterized heterozygous and homozygous transgenic mice that overexpress VEGF(165)b specifically in podocytes.
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- The study aimed to investigate how angiopoietin-1 (Ang1) affects the permeability of different types of microvessels, focusing on non-inflamed conditions and the cellular mechanisms involved.
- Ang1 was found to lower water permeability and enhance albumin retention in microvessels by affecting the endothelial glycocalyx, which is a layer that can influence vessel permeability.
- The findings suggest that Ang1 modifies microvessel permeability through mechanisms involving the endothelial glycocalyx, which could be relevant in understanding blood vessel behavior in both normal and inflamed states.