How a neurotransmitter drives brainwashing during sleep.

Pulsating blood vessels push fluid into and out of the brains of slumbering mice.

Fish could personalize cancer treatments.

The first clinical trial of zebrafish embryos acting as cancer "avatars" will start soon.

Methods to Manage Edema and Reduce Flap Compression in Postoperative Nursing Care Following Trauma to the Lower Extremity.

Lower extremity edema and compression are potential causes of poor soft tissue healing and flap failure for patients who suffer lower extremity trauma. This review summarizes techniques aimed at reducing edema and mechanical pressure in these patients as well as those undergoing soft tissue coverage techniques. We conducted a literature review for postoperative nursing management to reduce edema in the lower extremity, following traumatic injury.

Sequence specificity of an essential nuclear localization sequence in Mcm3.

Proteins with nuclear localization sequences (NLSs) are directed into the cell nucleus through interactions between the NLS and importin proteins. NLSs are generally short motifs rich in basic amino acids; however, identifying NLSs can be challenging due to the lack of a universally conserved sequence. In this study, we characterized the sequence specificity of an essential and conserved NLS in Mcm3, a subunit of the replicative DNA helicase.

Aging 'clocks' battle for science glory and cash.

Contest aims to improve molecular assays needed to test aging treatments.

Edit the messenger.

New treatments aim to counteract mutant genes by fixing the faulty RNA they produce.

Youth Engagement Synergy in Mental Health Legislation and Programming.

Youth engagement in implementing mental health legislation and programming is an intuitive best practice. However, well-intentioned efforts to work inclusively with youth are often perfunctory. Drawing from select community partnership models and insights from providers, public health advisors, and youth, we examine the typology, processes, and outcomes of youth engagement.

Hunt for longevity drugs gets new life.

Decades-old project has new funding and a new set of compounds to test.

Durable proteins appear to protect ovaries.

Studies find long-lived proteins are prevalent in the organs.

Drug development blossoms for rare, fatal bone disease.

Five drugs are now approved or in trials for genetic condition that triggers misplaced bone growth.

Communication breakdown.

Faulty messaging between organs could make us old.

Surgical Delay-Associated Mortality Risk Varies by Subtype in Loco-Regional Breast Cancer Patients in SEER-Medicare.

Substantial evidence supports that delay of surgery after breast cancer diagnosis is associated with increased mortality risk, leading to the introduction of a new Commission on Cancer quality measure for receipt of surgery within 60 days of diagnosis for non-neoadjuvant patients. Breast cancer subtype is a critical prognostic factor and determines treatment options; however, it remains unknown whether surgical delay-associated breast cancer-specific mortality (BCSM) risk differs by subtype. This retrospective cohort study aimed to assess whether the impact of delayed surgery on survival varies by subtype (hormone [HR]+/HER2-, HR-/HER2-, and HER2+) in patients with loco-regional breast cancer who received surgery as their first treatment between 2010-2017 using the SEER-Medicare.

Thinking and Enacting the Patient Medical Home Under Pandemic Conditions: A Qualitative Study From Primary Care in Alberta, Canada.

Background: The COVID-19 (C19) pandemic shocked primary care systems around the world. Those systems responded by supporting patients in the community, and acute care facilities in crisis. In Canada, the Patient Medical Home (PMH) is a widely adopted care model that aims to operationalize the tenets and principles of Primary Health Care (PHC) as developed since the Alma-Ata Declaration.

Outcomes of Distal Third Femur Fractures in Patients 18 Years and Older: A Pilot Study.

Introduction: The selection of the most optimal fixation method for fractures of the distal femur, whether intramedullary nail (NL), lateral locking plate (PL), or nail/plate (NP) is not always clear. This study retrospectively evaluates surgical patients with distal femur fractures and introduces a pilot study using cluster analysis to identify the most optimal fracture fixation method for a given fracture type.

Methods: This is a retrospective cohort study of patients 18 years and older with an isolated distal femur fracture who presented to our Level-1 trauma center between January 1, 2012, and December 31, 2022, and obtained NL, PL, or NP implants.

The feasibility of a novel 3D-Printed patient specific cutting guide for extended trochanteric osteotomies.

Background: The extended trochanteric osteotomy (ETO) is a surgical technique utilized to expose the intramedullary canal of the proximal femur, protect the soft tissues and promote reliable healing. However, imprecise execution of the osteotomy can lead to fracture, soft tissue injury, non-union, and unnecessary morbidity. We developed a technique to create patient specific, 3D-printed cutting guides to aid in accurate positioning of the ETO and improve osteotomy quality and outcomes.

First step taken toward artificial plant genome.

Scientists make partially synthetic version of moss chromosome, aiming to harness plant for industry.

SARS-CoV-2 sneezing explained.

Viral protein prods nerve cells, may be treatment target.

Successful rituximab therapy in adult-onset IgA vasculitis with diffuse alveolar hemorrhage and renal failure: a case report.

Background: Immunoglobulin A vasculitis (IgAV) is a rare condition that most commonly presents during childhood. Patients with adult-onset IgAV are more likely to exhibit severe symptoms at presentation with worse renal outcomes. Pulmonary manifestations of adult-onset IgAV have been described rarely in the literature and often indicate higher morbidity and mortality.

Massive study of dog aging likely to lose funding.

Organizers hope to save long-running project on canine aging and longevity.

A comparative effectiveness study of the breaking the cycle and Maxxine Wright intervention programs for substance-involved mothers and their children: study protocol.

Background: Children of substance-involved mothers are at especially high risk for exposure to adverse childhood experiences (ACEs) and poor mental health and development. Early interventions that support mothers, children, and the mother-child relationship have the greatest potential to reduce exposure to early adversity and the mental health problems associated with these exposures. Currently, there is a lack of evidence from the real-world setting demonstrating effectiveness and return on investment for intervention programs that focus on the mother-child relationship in children of substance-involved mothers.

Megaproject will chart human immune diversity.

Human Immunome Project's survey aims to improve drugs and vaccines.

User-Centered Design and Usability of a Culturally Adapted Virtual Survivorship Care App for Chinese Canadian Prostate Cancer Survivors: Qualitative Descriptive Study.

Background: Cultural adaptations of digital health innovations are a growing field. However, digital health innovations can increase health inequities. While completing exploratory work for the cultural adaptation of the Ned Clinic virtual survivorship app, we identified structural considerations that provided a space to design digitally connected and collective care.