Publications by authors named "Leslie Kenou"
Article Synopsis
- The study aimed to systematically review HIV-1 reservoirs in children and adolescents with perinatally acquired HIV, analyzing published data from various studies between 2002 and 2022.
- A total of 49 studies involving over 2,300 participants were included, revealing a high prevalence of archived-drug resistance mutations (ADRMs) across different regions, with significant findings regarding early antiretroviral therapy (ART) initiation impacting HIV-1 DNA levels.
- The conclusions emphasized that high ADRM prevalence and larger viral reservoirs are associated with late ART initiation and shorter periods of viral suppression, suggesting the need for early ART strategies in pediatric populations to improve treatment outcomes.
Characterization of the Viral Reservoirs Among HIV-1 Non-B Vertically Infected Adolescents Receiving Antiretroviral Therapy: Protocol for an Observational and Comparative Study in Cameroon.
Aubin Joseph Nanfack Georgia Elna Ambada Ndzengue Joseph Fokam Aude Christelle Ka'e Nelson Sonela Leslie Kenou
JMIR Res Protoc
November 2022
Article Synopsis
- Antiretroviral therapy (ART) effectively lowers HIV-1 levels to undetectable but requires lifelong use, as treatment cessation leads to viral rebound due to latent reservoirs in CD4+ T cells.
- Understanding the characteristics of these HIV reservoirs and their variability is crucial for developing a potential cure, with factors like treatment timing and immune response influencing them.
- The research aims to analyze immune and viral profiles of HIV-1 non-B infected adolescents in Cameroon to gather data for HIV cure research, including comparisons with HIV-negative peers.