Therapeutic efficacy of posaconazole in a murine model of disseminated trichosporonosis.

Objectives: To study the effect of the initiation time of posaconazole treatment from 1 to 3 days after systemic infection by Trichosporon asahii in mice.

Methods: BALB/c mice, 4-5 weeks old, were intravenously infected with 1 × 10(7) cfu/mouse of T. asahii.