Concomitant Antihyperalgesic and Antitumor Effects of Gabapentin in a Murine Cancer Pain Model.

Cancer pain may be the consequence of physical nerve compression by a growing tumor. We employed a murine model to study whether gabapentin was able to regulate tumor growth, in addition to controlling hyperalgesic symptoms. A fluorescent melanoma cell line (B16-BL6/Zs green) was inoculated into the proximity of the sciatic nerve in male C57BL/6 mice.

Age as a determinant factor for endotoxin induced uveitis.

Purpose: To determine if susceptibility to systemic endotoxin-induced uveitis is an age-related phenomenon in the rabbit.

Methods: Young and adult rabbits were injected intravenously with 2.5 microg/kg of E.