Publications by authors named "Leslie Anforth"
Article Synopsis
- The study evaluates the combination of the histone deacetylase inhibitor entinostat with immune checkpoint inhibitors (ICIs) nivolumab and ipilimumab in patients with advanced solid tumors, aiming to enhance treatment efficacy.
- Thirty-three patients participated in the trial, experiencing treatment-related side effects like fatigue and anemia, while the recommended phase II dosing was determined to be 3 mg of entinostat weekly, along with specified doses of nivolumab and ipilimumab.
- Results showed a 16% objective response rate, including a complete response in a case of triple-negative breast cancer, and a significant increase in CD8 effector to FoxP3 regulatory T cell ratios, highlighting the
Context: Sulfate is critical in the biotransformation of multiple compounds via sulfation. These compounds include neurotransmitters, proteoglycans, xenobiotics, and hormones such as dehydroepiandrosterone (DHEA). Sulfation reactions are thought to be rate-limited by endogenous sulfate concentrations.
View Article and Find Full Text PDFUsing genomic applications to glean insights into human biology, we systematically searched for nonsense single nucleotide variants (SNVs) that are rare in the general population but enriched in the Old Order Amish (Amish) due to founder effect. We identified two nonlinked, nonsense SNVs (R12X and W48X) in SLC13A1 (allele frequencies 0.29% and 0.
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