Publications by authors named "Lesley Fifer"
Background: In multiple myeloma, severe acute kidney injury due to myeloma cast nephropathy is caused by pathogenic free light chain immunoglobulin in serum. High cutoff haemodialysis (HCO-HD) can remove large quantities of free light chain immunoglobulin from serum, but its effect on clinical outcomes is uncertain. We therefore aimed to assess whether HCO-HD could increase the frequency of renal recovery in patients with de novo multiple myeloma, severe acute kidney injury, and myeloma cast nephropathy relative to treatment with standard high-flux haemodialysis (HF-HD).
View Article and Find Full Text PDFObjectives: The aim of this study was to report the long-term outcomes in patients with multiple myeloma (MM) who receive dialysis treatment for acute kidney injury (AKI) due to myeloma cast nephropathy and subsequently recover renal function.
Methods: Patients presenting with dialysis-dependent AKI secondary to myeloma cast nephropathy and subsequently recovering independent renal function between January 2005 and December 2012 were included in this study. Both renal and haematological parameters were collected at multiple time points as part of routine clinic practice.
Article Synopsis
- Chronic kidney disease (CKD) is prevalent and significantly increases the risk of hospitalization and cardiovascular issues, often without adequate treatment options based on clinical trials that exclude CKD patients.
- The ACQUATIK study aims to gather comprehensive data from over 4000 CKD patients over several years to analyze their treatment outcomes compared to those without CKD.
- This research will also explore how factors like age, sex, ethnicity, and socioeconomic status impact treatment and hospitalization rates, with ethical approval already granted for the study.