Communicating and not communicating with self and other. words, silence and the incommunicado self.

This contribution begins from Winnicott's introduction of the incommunicado self in his paper on communication to suggest that interiority and the psyche come to constitute the infantile world through the earliest environment and through solitude. The capacity to be with others and to be alone originate in an earlier state where communication both makes no sense and yet contains the origin of the life source through the baby's bodily experience of self and world. The world beyond the baby enables this through an other's care.

Presynaptic pH and vesicle fusion in Drosophila larvae neurones.

Both intracellular pH (pHi) and synaptic cleft pH change during neuronal activity yet little is known about how these pH shifts might affect synaptic transmission by influencing vesicle fusion. To address this we imaged pH- and Ca(2+) -sensitive fluorescent indicators (HPTS, Oregon green) in boutons at neuromuscular junctions. Electrical stimulation of motor nerves evoked presynaptic Ca(2+) i rises and pHi falls (∼0.