[The development of methods for experimental physiotherapy in patients with altered thyroid activity after exposure to ionizing radiation].

Pathogenic influence of Chernobyl-related factors was modelled with the view to study peculiarities of changes in the most important systems of the body induced by long-term low-dose ionizing radiation associated with hypo- and hyperthyroidism. Experimental rehabilitative therapy stipulated following methods of physico-pharmacological treatment: 1) course of general electrophoresis with chemical components of peloids; 2) the same course with Ethimisol added to the solution used for electrophoresis. Clinical follow-up of patients resided in the Chernobyl-stricken territories proved advisability of differentiated application of aforementioned methods according to prevailing thyroid symptoms.

[Analytical and experimental methods of determining and the significance of heat flow to the body from skin mud applications].

The paper describes mathematical and experimental methods estimating heat supply to the body from peloid applications. Rat experiments provided evidence on correlation between the energy supplied and body response in the form of alterations in heat generation and heat transfer.

[Study of the effects of various physiological endocrine relations at the liver level].

It is shown that predominance of male sex hormones in the rat organism decreases corticosterone in the liver, while that of female sex hormones increases it. The abundance of the thyroxine promotes a rise of blood in testosterone of males and reduces the estradiol in the females, but the blood content of corticosterone significantly decreases in blood and increases in the liver of rats of both sexes. While performing thyroidectomy the level of sex hormones reduces, but the content of glucocorticoid in the liver only slightly changes.

[Role of sex dimorphism in the pharmacological action of etimizol].

It has been shown that in female rats the level of ACTH, corticosterone in the blood, relative mass of adrenals, maintenance of T3, T4 in the serum and liver was significantly higher, but the activity of liver enzyme microsomes system was lower than in males; no sex differences were observed in myocardial creatine phosphokinase system. The influence of the etimizol on the female rats significantly speed up amidopyrine N-demethylation and biotransformation of hexobarbital. In males these systems react less on etimizol, but it reduces the speed of amidopyrine N-demethylation.

[Role of the microsomal enzymatic activity changes induced by peloid applications in the biotransformation and effect of pharmacological preparations].

Body exposure to the physical therapeutic factor (skin applications of heated peloid) leads to the acceleration of hydroxylase reactions proceeding on cytochrome P450. This circumstance determines the speeding up of the biotransformation of a number of pharmacological agents (strychnine, aniline, amidopyrine, etc.), and changes in the action of some drugs (phenobarbital, amidopyrine,, ethazole) affecting the drug-metabolizing microsomal system.

[Pharmacodynamics of anti-inflammatory preparations in body exposure to a physical therapeutic factor].

The analgetic and antipyretic action of acetylsalicylic acid is potentiated, whereas that of butadion and amidopyrine is decreased in the conditions of prior action of peloid skin applications (body temperature 42 degrees C). The effect of phenobarbital rises and that of butadion remains unchanged, whereas the inhibitory effect of ethazol revealed in the course of investigations of levelled under conditions of the action of the physical factor on the microsomal system. This leads to the changes in biotransformation and pharmacodynamics of the drugs.