Publications by authors named "Leseilane J Mampuru"

Article Synopsis
  • Researchers analyzed leaf extracts from three locations using RP-LC, TWIMS, and HRMS to identify different chemotypes and their chemical profiles.
  • They found 11 molecular species, including various flavonol glycosides and cucurbitane-type triterpenoids, with specific detection methods for each type.
  • Statistical analysis indicated that compounds balsaminol E and/or karavilagen E significantly contributed to distinguishing the geographical samples, and these compounds may be responsible for cytotoxic effects on HT-29 colon cancer cells.
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Recently, the use of the ribonucleotide reductase (RR) inhibitor hydroxyurea (HU) in combination with nucleoside analogs has gained attention as a potential strategy for anti-HIV-1 therapy. However, appeal for the long-term use of HU in HIV-1 infection may be limited by its propensity to induce hematopoietic toxicity. We report a comparison of the efficacy and bone marrow toxicity of HU (400 and 200 mg/kg/day) with the novel RR inhibitors and free radical-scavenging compounds didox (DX; 3,4-dihydroxybenzohydroxamic acid; 350 mg/kg/day) and trimidox (TX; 3,4,5-trihydroxybenzamidoxime; 175 mg/kg/day) in the murine AIDS (LPBM5 MuLV) model of retrovirus infection.

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