FOXP3 gene polymorphisms in preeclampsia.

Objective: To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.

Study Design: Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed.

Genetic variants in melatonin synthesis and signaling pathway are not associated with adolescent idiopathic scoliosis.

Study Design: Genetic association study investigating the association of genetic markers of melatonin signaling and biosynthesis with adolescent idiopathic scoliosis (AIS).

Objective: To determine whether gene polymorphisms related to the melatonin signaling or biosynthesis pathways are associated with AIS.

Summary Of Background Data: Data have been published on the potential role of gene polymorphisms for melatonin receptor (MTNR) 1B in predicting AIS.

Validation of DNA-based prognostic testing to predict spinal curve progression in adolescent idiopathic scoliosis.

Study Design: Validation of a prognostic DNA marker panel.

Objective: The goals of this study were to develop and test the negative predictive value of a prognostic DNA test for adolescent idiopathic scoliosis (AIS) and to establish clinically meaningful endpoints for the test.

Summary Of Background Data: Clinical features do not adequately predict which children diagnosed with minimal or mild AIS will have the progressive form of the disease; genetic markers associated with curve progression might offer clinically useful prognostic insights.

Polymorphisms in the promoter region of the interleukin-10 (IL-10) gene in women with cervical insufficiency.

Objective: Our objective was to determine whether polymorphisms in the promoter region of the interleukin-10 gene are more common in women with cervical insufficiency compared with controls.

Study Design: We conducted a case-control study. Histories and blood were obtained from 121 cases and 157 controls.