Oral fluid supplementation for the prevention of post-dural puncture headache: A noninferiority randomized controlled trial.

Aim(s): To investigate the impact of the absence of specific advice for oral fluid intake, compared to supplementation water intake on the occurrence of post-dural puncture headache.

Design: A prospective, open-label, non-inferiority, multicenter trial including hospitalized patients requiring a diagnostic lumbar puncture in seven hospitals in France.

Methods: Patients were randomly allocated (1:1) either to receive no specific advice on oral fluid intake (FREE-FLUID), or to be encouraged to drink 2 liters of water (CONTROL) within the 2 hours after lumbar puncture.

Comparing high and low amyloid producers in Alzheimer's disease: An in-depth analysis.

Background: The cerebrospinal fluid (CSF) Aβ ratio has proven to be a more reliable biomarker for amyloid pathology than CSF Aβ in Alzheimer's disease (AD), helping to correctly classify patients with positive tau biomarkers (T+) that would otherwise have remained outside of the AD continuum. It was shown that the Aβ ratio better captures a relative decrease of Aβ in patients with high CSF Aβ. However, whether patients with high-amyloid (HiA) AD, in whom A+ is defined by the Aβ ratio, exactly compare with their low-amyloid (LoA) counterparts, in whom A+ is defined by Aβ solely, deserves further analysis.

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis.

The ribosome-associated endoribonuclease Rae1 cleaves the Bacillus subtilis yrzI operon mRNA in a translation-dependent manner. This operon encodes up to four small peptides, S1027, YrzI, S1025, and S1024, whose functions are unknown. Here, we identified the function of YrzI and S1025 and deciphered the degradation pathways of the yrzI polycistronic mRNA.

Terrestrial-aquatic connectivity structures microbial communities during the formation of thermokarst lakes.

Rising air temperatures and permafrost degradation drive the erosion of palsas (permafrost mounds mainly composed of frozen peat and ice layers) and lead to the formation of thermokarst ponds and lakes, known for their high greenhouse gas (GHG) emissions. This study investigates the impact of permafrost soil erosion during thermokarst lake formation on microbial community structure and its implications for GHG dynamics in a highly degraded permafrost valley (Nunavik, northern Quebec, Canada). Samples were collected from a palsa, an emerging lake connected to the palsa, surrounding peat and soil pore water, and two mature lakes which are older, stratified, and less connected to the palsa.

[Socioeconomic impact of neurodevelopmental disorders in France].

Introduction: This study aims to assess the economic impact of delays and inadequate diagnosis and treatment for neurodevelopmental disorders (NDDs) in France, affecting 2 to 3 million individuals. Neurodevelopmental disorders, including autism spectrum disorder (ASD), learning disabilities, and attention deficit hyperactivity disorder (ADHD), are often described as "invisible" disabilities, but they generate significant societal costs.

Method: The study was conducted with the support of Ashoka France as part of a collaboration between Goodwill-Management and the Aloïs Association.

Long-term outcome of oesophageal atresia in adolescence (TransEAsome): a national French cohort study protocol.

Introduction: The project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics profiles using data from the world's biggest OA registry.

Methods And Analysis: is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group.

Isolated loss of vaccine immunity in the protein losings syndrome in a patient with a reverse one and a half ventricle palliation ("failing Fontan-like physiology").

Background: A subgroup of CHDs can only be treated palliatively through a Fontan circulation. In case of a failing Fontan situation, serum proteins are lost unspecifically and can also lead to a loss of vaccine antibodies. In a failing Fontan situation, heart transplantation may be the only feasible option.

Impact of Spatial Representation on the Quality of Prosthodontic Procedures.

Background: The correlation between the three-dimensional spatial representation (3DSR) abilities, specifically involving spatial orientation, spatial visualisation and spatial relationship, and the performance in exercises related to preclinical practical exams in fixed prosthodontics and removable partial denture is not studied.

Objective: Assess the correlation between the 3DSR abilities and the performance in exercises related to preclinical practical exams in fixed prosthodontics and removable partial denture carried out by second and third year dental students.

Materials And Methods: The 3DSR abilities (spatial orientation, spatial visualisation and spatial relationship) and the scores of preclinical practical exams in prosthetics were tested on 187 students.

Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in France.

Background: To evaluate the acceptance and safety of the treatment of newborns with nirsevimab (a long-acting monoclonal antibody designed to prevent respiratory syncytial virus infections) during the first season of implementation.

Methods: A longitudinal, prospective, single-centre cohort study was conducted from September 18th, 2023, to January 23rd, 2024 at Lille University Hospital (Lille, France). All newborns admitted to the hospital's maternity department during the study period and whose parents agreed to participate in the study were included.

Pulsatile gonadotropin-releasing hormone therapy: comparison of efficacy between functional hypothalamic amenorrhea and congenital hypogonadotropic hypogonadism.

Objective: To compare the ongoing pregnancy rate per initiated cycle between patients with functional hypothalamic amenorrhea (FHA) and patients with congenital hypogonadotropic hypogonadism (CHH) treated with pulsatile gonadotropin-releasing hormone (GnRH) administration.

Design: Retrospective monocentric cohort study conducted at the University Hospital of Lille from 2004 to 2022.

Subjects: A total of 141 patients diagnosed with central suprapituitary amenorrhea during infertility evaluation and subsequently treated with pulsatile GnRH therapy.

The Surface of Colloidal Metal-Organic Framework Nanoparticles Revealed by Vibrational Sum Frequency Scattering Spectroscopy.

Solvation shells strongly influence the interfacial chemistry of colloidal systems, from the activity of proteins to the colloidal stability and catalysis of nanoparticles. Despite their fundamental and practical importance, solvation shells have remained largely undetected by spectroscopy. Furthermore, their ability to assemble at complex but realistic interfaces with heterogeneous and rough surfaces remains an open question.

Impact of the 2nd, 3rd and 4th waves of the COVID-19 pandemic on wait times in head and neck cancer: A retrospective study in a French expert center.

Background: Treatment delay in head and neck cancer is a major problem, with impact on survival. The COVID-19 (coronavirus disease 2019) pandemic, evolving in waves around the world, caused diagnostic and therapeutic delays in certain cancers. The main objective of the present study was to analyze whether there was a change in wait times during three successive waves in our center.

Retrospective comparison of a weight-based dose every 2 weeks with a fixed dose every month: a real-life analysis of nivolumab in the treatment of advanced melanoma.

Nivolumab was first authorized at a weight-based dose (WBD) of 3 mg/kg every two weeks (Q2W). Since 2017, a fixed dose (FD) regimen [first 240 mg Q2W and then 480 mg per month (Q4W)] was allowed. The objective of the study was to compare a WBD regimen and an FD regimen with regard to effectiveness and safety.

Continuous positive airway pressure compliance in patients with mild cognitive impairment.

Purpose: Sleep apnoea (SA) is associated with accelerated cognitive decline in patients with mild cognitive impairment (MCI). Treatment of SA by continuous positive airway pressure (CPAP) may slow this decline if patients comply with the treatment. The aim of this study was to assess the rate of CPAP compliance in this population.

Long-term clinical and radiological results after scaphoid non-union treatment: a retrospective study about 60 cases.

Purpose: Scaphoid non-union treatment remains nonconsensual and is based on vascularized or non-vascularized bone grafting. This study aimed to evaluate with a long follow-up the functional, clinical, and radiological outcomes, reported complications and reoperations and studied non-union treatment prognostic factors.

Methods: Patients who had undergone bone graft surgery for scaphoid non-union were retrospectively reviewed.