Publications by authors named "Lere C"
Article Synopsis
- The study explores how enriched housing conditions affect seizure susceptibility in animals, comparing the effects of different living environments during the kindling procedure.
- Animals in enriched environments showed a delayed onset of epileptic seizures, suggesting these conditions may provide some protective benefits against developing epilepsy.
- The research also found an increase in newly generated brain cells in enriched environments, but this neurogenesis may be more of an adaptive response to seizures rather than a direct cause of delayed seizure development.
Article Synopsis
- A previous episode of epileptic seizures can temporarily protect the brain from damage caused by future seizures, a phenomenon known as 'epileptic tolerance.'
- Researchers used a rat model to induce seizures by injecting kainate, resulting in damage only to one side of the brain.
- After applying a second dose of kainate, neuroprotection was observed in the undamaged side of the brain, allowing for further study of neuroprotection mechanisms and how epilepsy affects brain responses and gene expression.
Prior epileptic episodes have been shown to decrease markedly the neuronal damage induced by a second epileptic episode, similar to the tolerance following an episode of mild ischemia. Endogenous neuroprotective effects mediated by various mechanisms have been put forward. This study investigated whether neuroprotection against the excitotoxic damage induced by re-exposure to an epileptic challenge can reflect a change in epileptic susceptibility.
View Article and Find Full Text PDF