The HesB Protein, MSMEG_4272, Is Required for In Vitro Growth and Iron Homeostasis.

A-type carrier (ATC) proteins are proposed to function in the biogenesis of Fe-S clusters, although their exact role remains controversial. The genome of encodes a single ATC protein, MSMEG_4272, which belongs to the HesB/YadR/YfhF family of proteins. Attempts to generate an _ deletion mutant by two-step allelic exchange were unsuccessful, suggesting that the gene is essential for in vitro growth.