Publications by authors named "Lequan Wen"
Background: Declining birth rates during the pandemic have led to concerns about the potential impact of the of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on fertility among men. As previous studies have had inconsistent conclusions, we conducted a meta-analysis to evaluate the effects of SARS-CoV-2 on semen parameters.
Methods: We searched several databases for articles published between 1 January 2020 and 25 July 2023.
Purpose: This study aimed to investigate the association between the CC-cytokine ligand-2 (CCL2) 2518A/G (rs1024611) single nucleotide polymorphism (SNP) and susceptibility to age-related macular degeneration (AMD).
Methods: PubMed, Embase, Web of Science, and other databases were searched for articles published before August 24, 2023. After searching, data extraction, and quality assessment, meta-analysis and trial sequential analysis were conducted using RevMan 5.
Article Synopsis
- Xp11.2 translocation renal cell carcinomas (tRCC) are rare and aggressive kidney cancers without effective diagnostic and treatment options, but researchers identified NMRK2 as a potential diagnostic marker specific to these tumors.
- The TFE3 fusion protein activates the NMRK2 gene, leading to its increased presence in tRCC tissues, and new RNA- and protein-based diagnostics were developed that match the accuracy of existing fluorescence methods.
- Functional studies indicated that NMRK2 encourages tRCC progression by enhancing the NAD/NADH ratio, and using compounds like NMN or NR could reverse negative effects caused by reduced NMRK2 levels, paving the way for potential new therapies.
Background: Although numerous case-control studies have explored the association between CC cytokine ligand-4 (CCL4) expression and cancer susceptibility, their results have been conflicting. This study aimed to determine the still-unknown connection of CCL4 rs10491121 and rs163450 polymorphisms with cancer susceptibility.
Methods: Several databases, such as Web of Science, PubMed, and EMBASE, were searched for papers published since the creation of the database until November 2, 2022.
Our study is aimed to access the efficacy and safety outcomes for coronavirus disease 2019 (COVID-19) patients treated with Paxlovid. According to inclusion and exclusion criteria, databases were used to retrieve articles from 1 January 2020 to 1 January 2023. Article screening, quality evaluation and data extraction were completed and cross-checked.
View Article and Find Full Text PDFBackground: Several case-control studies have been conducted on the relationship between rs3775290 C/T and rs3853839 C/G single nucleotide polymorphisms of the Toll-like receptor (TLR) gene and hand, foot, and mouth disease (HFMD) susceptibility and severity. This meta-analysis aimed to offer a systemic review of HFMD susceptibility and severity among the Chinese Han population associated with the C/T (rs3775290) polymorphism of the TLR3 gene or C/G (rs3853839) polymorphism of the TLR7 gene.
Methods: A computer search was conducted using PubMed, Web of Science, Embase, CNKI, CBM, VIP, and WanFang databases.
Article Synopsis
- - The systematic review examines the relationship between specific SNPs (1858 and 1123) in the PTPN22 gene and the risk of developing primary immune thrombocytopenia (ITP) by analyzing data from various databases up to June 2021.
- - The meta-analysis revealed that individuals with the TT genotype at SNP1858 are 5.01 times more likely to have ITP compared to those with the CC genotype, while G allele carriers at SNP1123 show a 23% increased risk compared to C allele carriers.
- - Although the findings are statistically significant, the study highlights limitations in the robustness of the results and suggests that further high-quality research is needed to confirm these associations, as the
Article Synopsis
- Chronic visceral pain, commonly seen in disorders like irritable bowel syndrome (IBS), often coexists with depression; the P2X7 receptor plays a key role in this connection.
- This study explored whether gallic acid, an anti-inflammatory and anti-depressive compound from traditional Chinese medicine, could alleviate both visceral pain and depression by targeting the P2X7 receptor expression.
- Results showed that gallic acid improved pain and depression in rats by lowering P2X7 receptor expression and altering inflammatory markers, indicating its potential as a treatment for these comorbid conditions.
Trigeminal Neuralgia (TN) refers to recurrent severe paroxysmal pain in the distribution area of the trigeminal nerve, which seriously affects the quality of life of patients. This research applied the chronic constriction injury of the infraorbital nerve (CCI-ION) approach to induce an animal model of TN in rats. The mechanical pain threshold of each group of rats was determined postoperatively; the expression of P2X7 receptor in trigeminal ganglion (TG) was assessed by qRT-PCR, immunofluorescence and Western blot; and the changes of the proinflammatory cytokines IL-1β and TNF-α in serum of rats were detected by ELISA.
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