KbhbXG: A Machine learning architecture based on XGBoost for prediction of lysine β-Hydroxybutyrylation (Kbhb) modification sites.

Lysine β-hydroxybutyrylation is an important post-translational modification (PTM) involved in various physiological and biological processes. In this research, we introduce a novel predictor KbhbXG, which utilizes XGBoost to identify β-hydroxybutyrylation modification sites based on protein sequence information. The traditional experimental methods employed for the identification of β-hydroxybutyrylated sites using proteomic techniques are both costly and time-consuming.

Image Quality Assessment Guided Collaborative Learning of Image Enhancement and Classification for Diabetic Retinopathy Grading.

Diabetic retinopathy (DR) is one of the most serious complications of diabetes and is a prominent cause of permanent blindness. However, the low-quality fundus images increase the uncertainty of clinical diagnosis, resulting in a significant decrease on the grading performance of the fundus images. Therefore, enhancing the image quality is essential for predicting the grade level in DR diagnosis.

Incentive strategy of safe and intelligent production in assembled steel plants from the perspective of evolutionary game.

Due to the numerous cross-operations and poor information communication, it is easy to cause production safety accidents in traditional assembled steel plants. The transformation and upgrading of smart production in the assembly steel plants is helpful to improve the efficiency of safety management. In order to effectively reduce the safety risks in the production of assembled steel components, this paper integrates policy incentives and safety supervision, constructs an evolutionary game model between the government and assembled steel producers, and analyzes the strategic evolution rules and stability conditions of stakeholders through the replication dynamics equation.

Polysaccharides improved the viscoelasticity, microstructure, and physical stability of ovalbumin-ferulic acid complex stabilized emulsion.

This study explored the mechanism underlying the interactions between polysaccharides and ovalbumin-ferulic acid (OVA-FA) and the effect of polysaccharides on OVA-FA-stabilized emulsions. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) were used to study the polysaccharide OVA-FA interactions mechanism and to resolve the changes in the protein secondary structure and crystal structure. OVA-FA-polysaccharide-stabilized emulsions were studied using confocal laser scanning microscopy (CLSM), and their rheological properties and stability were determined.

EECP improves markers of functional capacity regardless of underlying ranolazine therapy.

Objective: Enhanced external counterpulsation (EECP) and ranolazine are approved treatments for patients with chronic stable angina by the United States Food and Drug Administration (FDA). Whether EECP offers clinical benefits regardless of underlying ranolazine therapy needs further investigation.

Methods: This was a retrospective evaluation of patients referred to a specialized EECP center.

Self-stigma and quality of life among Chinese American breast cancer survivors: A serial multiple mediation model.

Objective: Despite the increasing scholarly attention toward self-stigma among Asian breast cancer survivors, research is limited about the underlying psychological mechanisms by which self-stigma may influence quality of life for this population. The present study investigated how self-stigma is associated with quality of life among Chinese American breast cancer survivors by examining the serial mediating effects of concerns about breast cancer, self-efficacy for coping with cancer, and depressive symptoms.

Methods: Chinese American breast cancer survivors (n = 112) completed a questionnaire packet assessing self-stigma related to breast cancer, concerns about breast cancer, self-efficacy for coping with cancer, depressive symptoms, and quality of life.