[The impact of the coronavirus pandemic on the quality of life and the formation of population immunity to the SARS-CoV-2 virus in the older generation 65+ group.].

The impact of the pandemic of the new coronavirus infection Covid-19 and the introduction of self-isolation on the quality of life of the older generation 65+ were analyzed, with an assessment of herd immunity among the study participants. The study protocol included 192 people who are employees of the Irkutsk Scientific Center, including 94 people of the older age group 65+. All participants were divided by us conditionally into four age groups.

[The possibilities for the prevention of incompetent tracheorrhaphy].

The present review of the literature is focused on the methods designed for the prevention of incompetent tracheorrhaphy. The main cause that dictates the necessity of strengthening the sutures is the risk of the development of the complications during the postoperative period following the surgical interventions. The incompetence of the tracheal anastomoses is known to occur in 3.

A Method for Microencapsulation of Cells and a Device for Its Realization.

The device for cell encapsulation makes it possible to fabricate microcapsules of a preset size with even smooth surface, without defects or adhesion to each other, with viable cells inside the capsule. The cells were derived from newborn piglet pancreases.

The level of free circulating mitochondrial DNA in blood as predictor of death in case of acute coronary syndrome.

Background: The efficacy of treating acute myocardial ischemic damages depends, to a large extent, on the development of technologies for predicting their course and outcome. The aim of this paper was to explore whether it would be possible to consider the content of free circulating mitochondrial DNA as a danger-associated molecular pattern for assessing the probability of death from myocardial infarction.

Methods: We have analyzed the clinical outcomes based on discharge summaries and autopsy reports obtained in the course of the PROTOCOL observational trial.

Experimental Model of Intervertebral Disk Mediated Postoperative Epidural Fibrosis.

Background: Postoperative epidural fibrosis (EF) after lumbar discectomy is the most common and at the same time controversial issue.

Purpose: The etiology and pathogenesis creates a lot of discussion and selection of methods of treatment and prevention continues.

Methods: LIV laminectomy with dura mater (DM) exposition was done in 24 rats, and then, 0.

[The methods for the treatment and prevention of cicatrix stenoses of trachea].

The objective of the present study was to analyze the current literature concerning mechanisms underlying the development of tracheal stenosis, new methods for the treatment and prevention of this condition. The main cause behind the formation of cicatrical stenosis of trachea is believed to be long-term artificial lung ventilation whereas the principal factors responsible for the injury to the tracheal wall include the impact of the cuff and the free end of the endotracheal tube, reflux of duodenal and gastric contents, concomitant infection, and the involvement of the autoimmune component. These pathogenic factors produce morphological changes in all layers of the tracheal wall with the formation of the granulation tissue the appearance of which serves as a forerunner of irreversible changes leading to tracheal stenosis.

Level of Blood Cell-Free Circulating Mitochondrial DNA as a Novel Biomarker of Acute Myocardial Ischemia.

Changes in the level of blood cell-free circulating mitochondrial DNA were examined during experimental adrenaline-induced myocardial injury in rats. The amount of mitochondrial DNA in the blood was significantly elevated at 48 and 72 h after subcutaneous injection of adrenaline solution, and it was accompanied by development of multiple small-focal myocardial ischemia. This suggests that the measured level of blood cell-free circulating mitochondrial DNA might be used as a biomarker of acute myocardial ischemia.

[Parathyreoidectomy in Rats Using Microsurgery and Medical Adhesive Sulfacrylate].

Background: One of the main difficulties in assessing the effectiveness of etiologic treatment of hypoparathyroidism is absence of its standardized model.

Objective: The aim of the study was to develop a method of hypoparathyroidism modeling.

Methods: Controlled nonrandomized study was performed on female Wistar rats aged 10 month.

[Transplantation of isolated hepatocytes in hepatic failure].

The authors review achievements in the field of prophylaxis and treatment of acute liver failure with donor's allo- and xenogenic isolated hepatocytes. Present-day clinical and experimental data on transplantation of hepatocytes evidence for their ability to produce a detoxicating action, to restore the lost functions of the affected part of the liver, to prevent death of hepatocytes caused by ischemia, to activate regeneration. This method is easy to conduct and obtained cells from one donor can by used for many recepients.