Magnesium, calcium and cancer.

Magnesium ion (Mg(2+)) and calcium ion (Ca(2+)) control a diverse and important range of cellular processes, such as gene transcription, cell proliferation, neoplastic transformation, immune response and therapeutic treatment. Their characteristic biologic antagonism makes it important to treat the most important aspects of that competitive behavior together. This synopsis aims to be a useful means of promoting further research on the relationship between both cations and human health affected by environmental conditions.

The paradoxical immuno-response of adenosine triphosphate effects.

The actual research on the paradoxical effects of ATP to obtain to optimal conditions of the immune response against certain pathologies. The ATP Paradox, after its interaction with iron or aluminum, which have shown important effects on carcinogenesis, suggests its implication in pathological systems in which overcalcification may play a role.

Aluminum, calcium ion and radiofrequency synergism in acceleration of lymphomagenesis.

This study that was done on lymphomagene-bearing mice indicates a synergism aluminum-radiofrequency which induces an early increase in mortality that is in concomitance with lymphoid elements proliferation and infiltration of spleen and liver. These two last phenomena were assessed by determination of the hypertrophic index (Growth Index) which is the organ weight to to the body weight ratio, as well as by the histopathological examination of the organ tissue. The importance of this synergism appears to be determined by the ionization at the physiological pH of the used aluminum complexes: much higher with lactate complex than with the citrate one.